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rdf:type |
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lifeskim:mentions |
umls-concept:C0003591,
umls-concept:C0004153,
umls-concept:C0026809,
umls-concept:C0242606,
umls-concept:C0332161,
umls-concept:C0441994,
umls-concept:C0542341,
umls-concept:C1121571,
umls-concept:C1517499,
umls-concept:C1519957,
umls-concept:C1801960,
umls-concept:C2347662
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pubmed:issue |
3
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pubmed:dateCreated |
2008-2-4
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pubmed:abstractText |
Transgenesis of human paraoxonase 1 (PON1), a HDL-associated enzyme that destroys lipid peroxides, has been reported to reduce early atherogenesis in mice. The present study explored the therapeutic potential of human PON1 gene transfer in old apolipoprotein E-deficient (apoE(-/-)) mice with advanced atherosclerosis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-10484417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-10484545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-10753938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-10831526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-11145939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-11238274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-11397713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-11524399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-11641234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-12039802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-12097824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-12135950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-12151850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-12588755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-12668499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-12829190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-12834320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-14600079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-15533870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-15578994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-15939049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-15997227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-16410455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-16415908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-16627808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-16723719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-16999997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-17536120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-8141836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-8232306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-862138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-9188442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-9712341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18059326-9721694
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
153
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
508-16
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18059326-Animals,
pubmed-meshheading:18059326-Aorta, Thoracic,
pubmed-meshheading:18059326-Apolipoproteins E,
pubmed-meshheading:18059326-Aryldialkylphosphatase,
pubmed-meshheading:18059326-Atherosclerosis,
pubmed-meshheading:18059326-Calcium,
pubmed-meshheading:18059326-Endothelium, Vascular,
pubmed-meshheading:18059326-Gene Transfer Techniques,
pubmed-meshheading:18059326-Homeostasis,
pubmed-meshheading:18059326-Humans,
pubmed-meshheading:18059326-Lipoproteins, LDL,
pubmed-meshheading:18059326-Mice,
pubmed-meshheading:18059326-Mice, Inbred C57BL,
pubmed-meshheading:18059326-Mice, Knockout,
pubmed-meshheading:18059326-Muscle, Smooth, Vascular,
pubmed-meshheading:18059326-Oxidative Stress,
pubmed-meshheading:18059326-Transfection,
pubmed-meshheading:18059326-Vasodilation
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pubmed:year |
2008
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pubmed:articleTitle |
Paraoxonase 1 gene transfer lowers vascular oxidative stress and improves vasomotor function in apolipoprotein E-deficient mice with pre-existing atherosclerosis.
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pubmed:affiliation |
Division of Pharmacology, University of Antwerp, Wilrijk, Belgium. pieter-jan.guns@ua.ac.be
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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