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18058545
Source:
http://linkedlifedata.com/resource/pubmed/id/18058545
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Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0011209
,
umls-concept:C0014898
,
umls-concept:C0061506
,
umls-concept:C0209738
,
umls-concept:C0560175
,
umls-concept:C0596448
,
umls-concept:C1706209
pubmed:issue
8-9
pubmed:dateCreated
2007-12-6
pubmed:abstractText
We report the synthesis of homo and heterodimers of 3TC conjugates. All new dimers were screened for their ability to inhibit HIV-1 in MT4 cell line and were compared to AZT alone and showed marked antiviral activity.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/100892832
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Anhydrides
,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents
,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Carriers
,
http://linkedlifedata.com/resource/pubmed/chemical/Glutarates
,
http://linkedlifedata.com/resource/pubmed/chemical/Lamivudine
,
http://linkedlifedata.com/resource/pubmed/chemical/glutaric anhydride
pubmed:status
MEDLINE
pubmed:issn
1525-7770
pubmed:author
pubmed-author:EngelsJoachim WJW
,
pubmed-author:LazrekH BHB
,
pubmed-author:SecristJackJ3rd
,
pubmed-author:VasseurJ JJJ
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1103-6
pubmed:meshHeading
pubmed-meshheading:18058545-Anhydrides
,
pubmed-meshheading:18058545-Anti-HIV Agents
,
pubmed-meshheading:18058545-Cell Line
,
pubmed-meshheading:18058545-Dimerization
,
pubmed-meshheading:18058545-Drug Carriers
,
pubmed-meshheading:18058545-Drug Delivery Systems
,
pubmed-meshheading:18058545-Drug Design
,
pubmed-meshheading:18058545-Glutarates
,
pubmed-meshheading:18058545-HIV-1
,
pubmed-meshheading:18058545-Humans
,
pubmed-meshheading:18058545-Lamivudine
pubmed:year
2007
pubmed:articleTitle
A glutaric acid ester as carrier system for sustained delivery of lamuvidine (3TC) dimers.
pubmed:affiliation
Faculté des Sciences Semlalia, Laboratoire de Chimie Bio-Organique, Marrakech, Maroc.
pubmed:publicationType
Journal Article
,
Research Support, Non-U.S. Gov't