Linked Life Data

18058544

Source:http://linkedlifedata.com/resource/pubmed/id/18058544

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8-9
pubmed:dateCreated
2007-12-6
pubmed:abstractText
The syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogues of O(6)-methylguanine and S(6)-methylthioguanine are described. The crystal structures and pK(a) values of these analogues are reported. In a standard substrate assay with the human repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analogue displayed activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1525-7770
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1099-102
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.
pubmed:affiliation
Centre for Chemical Biology, Department of Chemistry, University of Sheffield, Sheffield, United Kingdom.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't