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pubmed-article:18057742pubmed:dateCreated2007-12-6lld:pubmed
pubmed-article:18057742pubmed:abstractTextAs part of our program to develop potential imaging agents for ascorbate bioactivity in the brain, 5-O-(4'-iodobenzyl)-L-ascorbic acid was prepared through a seven-step sequence which involved C5-O-alkylation with p-iodobenzyl bromide in the presence of Ag2O and CaSO4 as the key step, starting from L-ascorbic acid. The scavenging activity of the p-iodobenzylated analog against 2,2-diphenyl-1-picrylhyrazyl (DPPH) radical was almost the same as that of L-ascorbic acid itself.lld:pubmed
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pubmed-article:18057742pubmed:pagination1700-3lld:pubmed
pubmed-article:18057742pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:18057742pubmed:year2007lld:pubmed
pubmed-article:18057742pubmed:articleTitleAscorbate analogs for use in medical imaging: synthesis and radical scavenging activity of 5-O-(4'-iodobenzyl)-L-ascorbic acid.lld:pubmed
pubmed-article:18057742pubmed:affiliationGraduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.lld:pubmed
pubmed-article:18057742pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18057742pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed