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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-12-6
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pubmed:abstractText |
As part of our program to develop potential imaging agents for ascorbate bioactivity in the brain, 5-O-(4'-iodobenzyl)-L-ascorbic acid was prepared through a seven-step sequence which involved C5-O-alkylation with p-iodobenzyl bromide in the presence of Ag2O and CaSO4 as the key step, starting from L-ascorbic acid. The scavenging activity of the p-iodobenzylated analog against 2,2-diphenyl-1-picrylhyrazyl (DPPH) radical was almost the same as that of L-ascorbic acid itself.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0009-2363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1700-3
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18057742-Alkylation,
pubmed-meshheading:18057742-Ascorbic Acid,
pubmed-meshheading:18057742-Biphenyl Compounds,
pubmed-meshheading:18057742-Diagnostic Imaging,
pubmed-meshheading:18057742-Free Radical Scavengers,
pubmed-meshheading:18057742-Indicators and Reagents,
pubmed-meshheading:18057742-Magnetic Resonance Spectroscopy,
pubmed-meshheading:18057742-Picrates,
pubmed-meshheading:18057742-Spectrometry, Mass, Electrospray Ionization,
pubmed-meshheading:18057742-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:18057742-Spectrophotometry, Infrared
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pubmed:year |
2007
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pubmed:articleTitle |
Ascorbate analogs for use in medical imaging: synthesis and radical scavenging activity of 5-O-(4'-iodobenzyl)-L-ascorbic acid.
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pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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