Linked Life Data

18056914

Source:http://linkedlifedata.com/resource/pubmed/id/18056914

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
415
pubmed:dateCreated
2007-12-6
pubmed:abstractText
The conventional view of cytokine signaling is that receptors transmit information to the nucleus without leaving the plasma membrane. However, accumulating data suggest that some membrane receptors may signal by dissociating from the plasma membrane and translocating to the nucleus, where they direct the transcriptional machinery. One example is the growth hormone receptor (GHR), which has been observed in the nuclei of various normal and neoplastic tissues. Waters and colleagues now present new mechanistic data describing how GHR might localize to the nucleus and influence gene transcription. These findings may have implications for the way we think about cytokine signaling.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1525-8882
pubmed:author
pubmed:issnType
Electronic
pubmed:day
4
pubmed:volume
2007
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
pe69
pubmed:dateRevised
2009-12-9
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Nuclear localization of growth hormone receptor: another age of discovery for cytokine action?
pubmed:affiliation
Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612, USA. swanson@uic.edu
pubmed:publicationType
Journal Article, Review