|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001675,
umls-concept:C0021641,
umls-concept:C0085536,
umls-concept:C0205275,
umls-concept:C0205734,
umls-concept:C0332281,
umls-concept:C0474643,
umls-concept:C1414925,
umls-concept:C1419102,
umls-concept:C1518422,
umls-concept:C2603343
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2008-2-29
|
|
pubmed:abstractText |
We previously demonstrated the presence of two different populations among individuals with adult-onset autoimmune diabetes: those having either a high titer or a low titer of antibodies to GAD (GADAs). Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) has been identified as a new susceptibility gene for type 1 diabetes and other autoimmune diseases. The aim of the present study was to evaluate whether the phenotypic heterogeneity of adult-onset autoimmune diabetes based on the GADA titer is associated with the PTPN22 C1858T polymorphism.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1935-5548
|
|
pubmed:author |
pubmed-author:BosiEmanueleE,
pubmed-author:BuzzettiRaffaellaR,
pubmed-author:CapizziMarcoM,
pubmed-author:CossuEfisioE,
pubmed-author:FalorniAlbertoA,
pubmed-author:GiaccariAndreaA,
pubmed-author:NIRAD Study Group,
pubmed-author:PetroneAntonioA,
pubmed-author:PozzilliPaoloP,
pubmed-author:SuraciConcettaC,
pubmed-author:TibertiClaudioC
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
31
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
534-8
|
|
pubmed:meshHeading |
pubmed-meshheading:18056891-Adult,
pubmed-meshheading:18056891-Alleles,
pubmed-meshheading:18056891-Autoantibodies,
pubmed-meshheading:18056891-Chi-Square Distribution,
pubmed-meshheading:18056891-Diabetes Mellitus, Type 1,
pubmed-meshheading:18056891-Female,
pubmed-meshheading:18056891-Gene Frequency,
pubmed-meshheading:18056891-Genetic Predisposition to Disease,
pubmed-meshheading:18056891-Genotype,
pubmed-meshheading:18056891-Glutamate Decarboxylase,
pubmed-meshheading:18056891-HLA Antigens,
pubmed-meshheading:18056891-Humans,
pubmed-meshheading:18056891-Male,
pubmed-meshheading:18056891-Middle Aged,
pubmed-meshheading:18056891-Phenotype,
pubmed-meshheading:18056891-Polymorphism, Single Nucleotide,
pubmed-meshheading:18056891-Protein Tyrosine Phosphatase, Non-Receptor Type 22
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with high GAD antibody titer in latent autoimmune diabetes in adults: Non Insulin Requiring Autoimmune Diabetes (NIRAD) Study 3.
|
|
pubmed:affiliation |
Department of Clinical Science, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Rome, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
