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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
50
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pubmed:dateCreated |
2007-12-14
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pubmed:abstractText |
Murine granulocytic cells, in becoming leukemic, need to acquire enhanced self-generation and a capacity for autocrine growth stimulation. Mice transplanted with bone marrow cells transduced with the Mixl1 homeobox gene develop a very high frequency of myeloid leukemia derived from the transduced cells. Preleukemic mice contained a high frequency of transduced clonogenic granulocytic cells. They exhibited an abnormally high capacity for self-replication and could generate immortalized granulocytic cell lines that remained absolutely dependent on either GM-CSF or IL-3 and were not leukemic. Organs from mice repopulated by marrow cells transduced either with Mixl1 or the control murine stem cell virus vector exhibited a capacity to produce IL-3 in vitro, activity being highest with the lungs, marrow, bladder, and thymus. Supporting evidence for the in vivo production of IL-3 was the frequent development of mast cells in the marrow. Overexpression of Mixl1 appears capable of inducing an abnormal self-renewal capacity in granulocytic precursors. Aberrant production of IL-3 was not present in the continuous Mixl cell lines and was therefore not in itself likely to be a leukemogenic change but it could support the enhanced survival and proliferation of the Mixl1 granulocytic populations until a final leukemogenic mutation occurs in them.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-11480567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-12351808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-15226173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-15522959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-1689277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-17060613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-17347684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-1978323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-2108861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-2653457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-3493174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-3528176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-7544853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-8104786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-8501982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-9242667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-9324276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-9808572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18056627-9885210
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
20013-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18056627-Animals,
pubmed-meshheading:18056627-Bone Marrow,
pubmed-meshheading:18056627-Bone Marrow Transplantation,
pubmed-meshheading:18056627-Cell Differentiation,
pubmed-meshheading:18056627-Cells, Cultured,
pubmed-meshheading:18056627-Homeodomain Proteins,
pubmed-meshheading:18056627-Interleukin-3,
pubmed-meshheading:18056627-Mast Cells,
pubmed-meshheading:18056627-Mice,
pubmed-meshheading:18056627-Mice, Inbred C57BL,
pubmed-meshheading:18056627-Preleukemia
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pubmed:year |
2007
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pubmed:articleTitle |
The preleukemic state of mice reconstituted with Mixl1-transduced marrow cells.
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pubmed:affiliation |
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia. metcalf@wehi.edu.au
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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