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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2007-12-6
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pubmed:abstractText |
Glioblastoma multiforme is the most frequent primary brain tumor in adults and represents one of the most lethal malignancies with a median survival of 12-16 months. We have previously shown that an oncolytic measles virus derivative expressing soluble human carcinoembryonic antigen (MV-CEA) has significant antitumor activity against glioblastoma multiforme cell lines and xenografts. Radiation therapy (RT) represents one of the mainstays of glioma treatment. Here we tested the hypothesis that the combination of RT with MV-CEA would have synergistic activity against gliomas.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:CarlsonBrettB,
pubmed-author:DeckerPaul APA,
pubmed-author:GalanisEvanthiaE,
pubmed-author:JamesC DavidCD,
pubmed-author:LiuChunshengC,
pubmed-author:ParaskevakouGeorgiaG,
pubmed-author:PetellCory ACA,
pubmed-author:RussellStephen JSJ,
pubmed-author:SarkariaJann NJN,
pubmed-author:SchroederMarkM,
pubmed-author:WuWentingW,
pubmed-author:ZollmanPaula JPJ
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7155-65
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pubmed:meshHeading |
pubmed-meshheading:18056196-Animals,
pubmed-meshheading:18056196-Brain Neoplasms,
pubmed-meshheading:18056196-Carcinoembryonic Antigen,
pubmed-meshheading:18056196-Caspase 8,
pubmed-meshheading:18056196-Cell Line, Tumor,
pubmed-meshheading:18056196-Combined Modality Therapy,
pubmed-meshheading:18056196-Death Domain Receptor Signaling Adaptor Proteins,
pubmed-meshheading:18056196-Glioblastoma,
pubmed-meshheading:18056196-Humans,
pubmed-meshheading:18056196-Measles virus,
pubmed-meshheading:18056196-Mice,
pubmed-meshheading:18056196-Mice, Inbred BALB C,
pubmed-meshheading:18056196-Mice, Nude,
pubmed-meshheading:18056196-Oncolytic Virotherapy,
pubmed-meshheading:18056196-Xenograft Model Antitumor Assays
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pubmed:year |
2007
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pubmed:articleTitle |
Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme.
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pubmed:affiliation |
Molecular Medicine Program, Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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