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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2007-12-6
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pubmed:abstractText |
Promoter hypermethylation of, for example, tumor-suppressor genes, is considered to be an important step in cancerogenesis and a negative risk factor for survival in patients with myelodysplastic syndromes (MDS); however, its role for response to therapy has not been determined. This study was designed to assess the effect of methylation status on the outcome of conventional induction chemotherapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:AggerholmAnniA,
pubmed-author:AntunovicPetarP,
pubmed-author:AstermarkJanJ,
pubmed-author:BernellPerP,
pubmed-author:EngströmLena-MariaLM,
pubmed-author:GrövdalMichaelM,
pubmed-author:Hellström-LindbergEvaE,
pubmed-author:HoklandPeterP,
pubmed-author:JacobsenSten EirikSE,
pubmed-author:KhanRasheedR,
pubmed-author:KjeldsenLarsL,
pubmed-author:LinderOlleO,
pubmed-author:NilssonLarsL,
pubmed-author:ObergGunnarG,
pubmed-author:OlssonAnnaA,
pubmed-author:PorwitAnnaA,
pubmed-author:TangenJon MagnusJM,
pubmed-author:WallvikJonasJ
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7107-12
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pubmed:meshHeading |
pubmed-meshheading:18056190-Age Factors,
pubmed-meshheading:18056190-Aged,
pubmed-meshheading:18056190-Aged, 80 and over,
pubmed-meshheading:18056190-Antigens, CD34,
pubmed-meshheading:18056190-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:18056190-Bone Marrow Cells,
pubmed-meshheading:18056190-Cadherins,
pubmed-meshheading:18056190-Cyclin-Dependent Kinase Inhibitor p15,
pubmed-meshheading:18056190-Cytidine,
pubmed-meshheading:18056190-DNA Methylation,
pubmed-meshheading:18056190-Daunorubicin,
pubmed-meshheading:18056190-Female,
pubmed-meshheading:18056190-Humans,
pubmed-meshheading:18056190-Kruppel-Like Transcription Factors,
pubmed-meshheading:18056190-Leukemia, Myelomonocytic, Chronic,
pubmed-meshheading:18056190-Male,
pubmed-meshheading:18056190-Middle Aged,
pubmed-meshheading:18056190-Myelodysplastic Syndromes,
pubmed-meshheading:18056190-Prospective Studies,
pubmed-meshheading:18056190-Remission Induction,
pubmed-meshheading:18056190-Treatment Outcome
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pubmed:year |
2007
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pubmed:articleTitle |
Negative effect of DNA hypermethylation on the outcome of intensive chemotherapy in older patients with high-risk myelodysplastic syndromes and acute myeloid leukemia following myelodysplastic syndrome.
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pubmed:affiliation |
Division of Haematology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Denmark.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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