| pubmed-article:18054860 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18054860 | lifeskim:mentions | umls-concept:C0439826 | lld:lifeskim |
| pubmed-article:18054860 | lifeskim:mentions | umls-concept:C0678558 | lld:lifeskim |
| pubmed-article:18054860 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18054860 | pubmed:dateCreated | 2007-12-6 | lld:pubmed |
| pubmed-article:18054860 | pubmed:abstractText | Olfactory sensory neurons (OSNs) form synapses with local interneurons and second-order projection neurons to form stereotyped olfactory glomeruli. This primary olfactory circuit is hard-wired through the action of genetic cues. We asked whether individual glomeruli have the capacity for stimulus-evoked plasticity by focusing on the carbon dioxide (CO2) circuit in Drosophila. Specialized OSNs detect this gas and relay the information to a dedicated circuit in the brain. Prolonged exposure to CO2 induced a reversible volume increase in the CO2-specific glomerulus. OSNs showed neither altered morphology nor function after chronic exposure, but one class of inhibitory local interneurons showed significantly increased responses to CO2. Two-photon imaging of the axon terminals of a single PN innervating the CO2 glomerulus showed significantly decreased functional output following CO2 exposure. Behavioral responses to CO2 were also reduced after such exposure. We suggest that activity-dependent functional plasticity may be a general feature of the Drosophila olfactory system. | lld:pubmed |
| pubmed-article:18054860 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18054860 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18054860 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18054860 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18054860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18054860 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18054860 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18054860 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:18054860 | pubmed:author | pubmed-author:OrtP JPJ | lld:pubmed |
| pubmed-article:18054860 | pubmed:author | pubmed-author:KellerAndreas... | lld:pubmed |
| pubmed-article:18054860 | pubmed:author | pubmed-author:SachseSilkeS | lld:pubmed |
| pubmed-article:18054860 | pubmed:author | pubmed-author:VosshallLesli... | lld:pubmed |
| pubmed-article:18054860 | pubmed:author | pubmed-author:OkadaRyuichiR | lld:pubmed |
| pubmed-article:18054860 | pubmed:author | pubmed-author:TanakaNobuaki... | lld:pubmed |
| pubmed-article:18054860 | pubmed:author | pubmed-author:RueckertErrol... | lld:pubmed |
| pubmed-article:18054860 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18054860 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:18054860 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:18054860 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18054860 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18054860 | pubmed:pagination | 838-50 | lld:pubmed |
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| pubmed-article:18054860 | pubmed:meshHeading | pubmed-meshheading:18054860... | lld:pubmed |
| pubmed-article:18054860 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:18054860 | pubmed:articleTitle | Activity-dependent plasticity in an olfactory circuit. | lld:pubmed |
| pubmed-article:18054860 | pubmed:affiliation | Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, Box 63, New York, NY 10065, USA. | lld:pubmed |
| pubmed-article:18054860 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18054860 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:18054860 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18054860 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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