Previous studies have evaluated the effect of modafinil on residual excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea syndrome (OSAS) under effective CPAP treatment. Even though those trials also used placebo groups, we suppose that the placebo effect might influence the patients' response to modafinil.
Sleep Medicine and Biology Discipline, Psychobiology Department, Universidade Federal de São Paulo, Napoleão de Barros 925, São Paulo 04024-002, SP Brazil. lia@psicobio.epm.br