Source:http://linkedlifedata.com/resource/pubmed/id/18053604
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2008-1-7
|
| pubmed:abstractText |
In this study, we found that a certain motor branch of glossopharyngeal (IX) motor nerves stably exhibits not only inspiratory activity but also expiratory activity with pons removal in neonatal rat brainstem-spinal cord preparations in vitro. Because this finding indicates that IX expiratory activity is masked by an inhibitory mechanism operating in the pons, we sought to determine the candidate neurons that exert an inhibitory effect on IX expiratory activity. IX expiratory activity was observed when only the pons was perfused with noradrenaline (NA) or clonidine (alpha2 adrenergic receptor agonist), but not when NA and yohimbine (alpha2 adrenergic receptor antagonist) were perfused together. IX expiratory activity was also observed following the removal of the dorsal pons but not the ventral pons. The local administration of clonidine into the bilateral locus coeruleus (LC) evoked burst discharges during the expiratory phase in the IX motor rootlet. These results suggest that neurons in the LC that possess an alpha2 adrenergic receptor on the membrane surface exert a tonic inhibitory effect on IX expiratory activity in neonatal rat brainstem-spinal cord preparations.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-2 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-2
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0168-0102
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2-9
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:18053604-Action Potentials,
pubmed-meshheading:18053604-Adrenergic alpha-2 Receptor Agonists,
pubmed-meshheading:18053604-Adrenergic alpha-Agonists,
pubmed-meshheading:18053604-Adrenergic alpha-Antagonists,
pubmed-meshheading:18053604-Aging,
pubmed-meshheading:18053604-Animals,
pubmed-meshheading:18053604-Animals, Newborn,
pubmed-meshheading:18053604-Exhalation,
pubmed-meshheading:18053604-Glossopharyngeal Nerve,
pubmed-meshheading:18053604-Locus Coeruleus,
pubmed-meshheading:18053604-Microinjections,
pubmed-meshheading:18053604-Neural Inhibition,
pubmed-meshheading:18053604-Neural Pathways,
pubmed-meshheading:18053604-Neurons,
pubmed-meshheading:18053604-Norepinephrine,
pubmed-meshheading:18053604-Organ Culture Techniques,
pubmed-meshheading:18053604-Rats,
pubmed-meshheading:18053604-Rats, Sprague-Dawley,
pubmed-meshheading:18053604-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:18053604-Respiratory Center,
pubmed-meshheading:18053604-Spinal Cord,
pubmed-meshheading:18053604-Synaptic Transmission
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Possible involvement of neurons in locus coeruleus in inhibitory effect on glossopharyngeal expiratory activity in a neonatal rat brainstem-spinal cord preparation in vitro.
|
| pubmed:affiliation |
First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka, Japan. yaman2@dent.osaka-u.ac.jp
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|