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rdf:type |
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lifeskim:mentions |
umls-concept:C0018957,
umls-concept:C0023418,
umls-concept:C0030705,
umls-concept:C0205263,
umls-concept:C0205430,
umls-concept:C0231335,
umls-concept:C0333678,
umls-concept:C0500222,
umls-concept:C1283828,
umls-concept:C1504389,
umls-concept:C1515895,
umls-concept:C1710360
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pubmed:issue |
3
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pubmed:dateCreated |
2008-1-25
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pubmed:abstractText |
Allogeneic peripheral blood stem cell CD34(+)-selected transplantation followed by donor lymphocyte infusion (DLI) to maximize graft-versus-leukaemia effect while avoiding graft-versus-host disease was investigated in 22 paediatric patients with acute myeloid leukaemia (n = 10) or acute lymphoblastic leukaemia (n = 12). Patients were grafted with a median (range) 6 x 10(6) (2-31 x 10(6))/kg CD34(+) cells and 1.1 x 10(4) (0.2-3.9 x 10(4)) CD3(+) cells. Seventy-five DLI were performed with no complications. Median time (range) to neutrophil and platelet engraftment was 13 (11-15) and 12 d (8-13) respectively. Probability of relapse and disease-free survival was 23 +/- 9% and 72 +/- 6% respectively (median follow-up of 15 months).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1365-2141
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
340-3
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pubmed:meshHeading |
pubmed-meshheading:18053071-Adolescent,
pubmed-meshheading:18053071-Antigens, CD3,
pubmed-meshheading:18053071-Antigens, CD34,
pubmed-meshheading:18053071-Antineoplastic Agents,
pubmed-meshheading:18053071-Child,
pubmed-meshheading:18053071-Child, Preschool,
pubmed-meshheading:18053071-Disease-Free Survival,
pubmed-meshheading:18053071-Female,
pubmed-meshheading:18053071-Graft vs Leukemia Effect,
pubmed-meshheading:18053071-Humans,
pubmed-meshheading:18053071-Infant,
pubmed-meshheading:18053071-Leukemia, Myeloid, Acute,
pubmed-meshheading:18053071-Lymphocyte Transfusion,
pubmed-meshheading:18053071-Male,
pubmed-meshheading:18053071-Peripheral Blood Stem Cell Transplantation,
pubmed-meshheading:18053071-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:18053071-Probability,
pubmed-meshheading:18053071-Prospective Studies,
pubmed-meshheading:18053071-Recurrence,
pubmed-meshheading:18053071-Stem Cells,
pubmed-meshheading:18053071-Transplantation, Homologous,
pubmed-meshheading:18053071-Transplantation Chimera,
pubmed-meshheading:18053071-Transplantation Conditioning,
pubmed-meshheading:18053071-Vidarabine
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pubmed:year |
2008
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pubmed:articleTitle |
Intentional induction of mixed haematopoietic chimerism as platform for cellular therapy after HLA-matched allogeneic stem cell transplantation in childhood leukaemia patients.
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pubmed:affiliation |
Division of Paediatric Hematology-Oncology, Haematopoietic Stem Cell transplantation Unit and Cellular Therapy, Hospital Niño Jesús, Madrid, Spain.
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pubmed:publicationType |
Journal Article
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