Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1992-5-5
pubmed:abstractText
Epidemiologic data show that the organ affinity of Streptococcus pneumoniae varies across serotypes. As a result of this heterogeneous distribution, exposure to antimicrobials is greater for serotypes 6, 14, 19 and 23. Most strains with resistance to antimicrobials are found among these four serotypes. Virulence of the various serotypes of pneumococci varies with adhesion, enzyme secretion, and resistance to phagocytosis. In a mouse model of experimental septicemia, neither the origin of strains nor the acquisition of a resistant phenotype modified virulence, which appeared as an intrinsic feature specific to each phenotype. Strains belonging to serotypes 6, 14, 19 and 23 with or without resistance to antimicrobials were only very rarely virulent in the experimental model used. As an indirect result, resistance to antimicrobials and virulence were inversely related among the strains of S. pneumoniae tested.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0369-8114
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
984-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
[Relationship between virulence and resistance to antibiotics in pneumococci. Contribution of experimental data obtained in an animal model].
pubmed:affiliation
Clinique de Réanimation des Maladies Infectieuses du P Vachon, INSERM U 13, Hôpital Bichat-Claude Bernard, Paris, France.
pubmed:publicationType
Journal Article, English Abstract