Linked Life Data

1805139

Source:http://linkedlifedata.com/resource/pubmed/id/1805139

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1992-5-5
pubmed:abstractText
Intrapleural administration of elastase was found to induce pulmonary emphysema identical to that seen after an endotracheal instillation of elastase in 33% of cats and 14% of rats given the treatment [15]. This experiment was repeated using hamsters, a species extremely sensitive to elastolytic factors reaching the lung via the airways. Linear intercept measurements (Lm) demonstrated no evidence of emphysema or alveolar dilatation four weeks after an intrapleural infusion of elastase, whereas quantified lung heterogeneity reached 40%, i.e., twice the control value; 17% of treated hamsters exhibited a statistically significant increase in heterogeneity of the right or left lung. These findings suggest that occurrence of alveolar dilatation after administration of a protease is dependent on access of the enzyme to the lung; if the enzyme fails to access the lung, abnormal lung heterogeneity may develop: this anomaly reflects a strong statistical likelihood of a disease state with or without concomitant emphysema, as was found in other species under identical conditions.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0369-8114
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
978-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
[Quantimetry and lung heterogeneity in hamsters (Mesocricetus auratus) treated with endotracheal or intrapleural infusion of elastase. Individual and contralateral variations].
pubmed:affiliation
Unité 14 INSERM Physiopathologie Respiratoire, Vandoeuvre-Les-Nancy, France.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract