| pubmed-article:1805098 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1805098 | lifeskim:mentions | umls-concept:C0009063 | lld:lifeskim |
| pubmed-article:1805098 | lifeskim:mentions | umls-concept:C0020291 | lld:lifeskim |
| pubmed-article:1805098 | lifeskim:mentions | umls-concept:C0007447 | lld:lifeskim |
| pubmed-article:1805098 | lifeskim:mentions | umls-concept:C0024360 | lld:lifeskim |
| pubmed-article:1805098 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:1805098 | lifeskim:mentions | umls-concept:C0031669 | lld:lifeskim |
| pubmed-article:1805098 | lifeskim:mentions | umls-concept:C0002611 | lld:lifeskim |
| pubmed-article:1805098 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1805098 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:1805098 | lifeskim:mentions | umls-concept:C0145675 | lld:lifeskim |
| pubmed-article:1805098 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:1805098 | pubmed:dateCreated | 1992-5-4 | lld:pubmed |
| pubmed-article:1805098 | pubmed:abstractText | Cetyltrimethylammonium and n-octadecyldimethylsulfonium bromides inhibit the Clostridium perfringens phospholipase C-catalyzed hydrolysis of 1-S-phosphocholine-2-O-hexadecanoyl-1-mercapto-2-ethanol (1) at pH 7.5, 37 degrees C, mu = 0.15 with KCl. Mixed micelles containing 1 and either inhibitor are substrates for the enzyme and the fraction of activity remaining is a monotonic, but non-linear function of the mole fraction of inhibitor. Simple saturation kinetics are observed as the concentration of 1 is increased in mixed micelles containing a constant mole fraction of inhibitor. Inhibition constants for cetyltrimethylammonium and n-octadecyldimethylsulfonium bromides are 0.66 +/- 0.04 and 0.25 +/- 0.02 mM, respectively. The data suggest that the significant inhibition previously observed for soluble alkyldisulfonium salts (K50 for dodecamethylene-bis(dimethylsulfonium) bromide, 27 microM) is dependent upon bifunctional cationic interactions rather than hydrophobic binding. | lld:pubmed |
| pubmed-article:1805098 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1805098 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1805098 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1805098 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1805098 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1805098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1805098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1805098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1805098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1805098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1805098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1805098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1805098 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1805098 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1805098 | pubmed:issn | 0024-4201 | lld:pubmed |
| pubmed-article:1805098 | pubmed:author | pubmed-author:McMahonR FRF | lld:pubmed |
| pubmed-article:1805098 | pubmed:author | pubmed-author:SnyderW RWR | lld:pubmed |
| pubmed-article:1805098 | pubmed:author | pubmed-author:YoungP RPR | lld:pubmed |
| pubmed-article:1805098 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1805098 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:1805098 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1805098 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1805098 | pubmed:pagination | 957-9 | lld:pubmed |
| pubmed-article:1805098 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:1805098 | pubmed:meshHeading | pubmed-meshheading:1805098-... | lld:pubmed |
| pubmed-article:1805098 | pubmed:meshHeading | pubmed-meshheading:1805098-... | lld:pubmed |
| pubmed-article:1805098 | pubmed:meshHeading | pubmed-meshheading:1805098-... | lld:pubmed |
| pubmed-article:1805098 | pubmed:meshHeading | pubmed-meshheading:1805098-... | lld:pubmed |
| pubmed-article:1805098 | pubmed:meshHeading | pubmed-meshheading:1805098-... | lld:pubmed |
| pubmed-article:1805098 | pubmed:meshHeading | pubmed-meshheading:1805098-... | lld:pubmed |
| pubmed-article:1805098 | pubmed:meshHeading | pubmed-meshheading:1805098-... | lld:pubmed |
| pubmed-article:1805098 | pubmed:meshHeading | pubmed-meshheading:1805098-... | lld:pubmed |
| pubmed-article:1805098 | pubmed:meshHeading | pubmed-meshheading:1805098-... | lld:pubmed |
| pubmed-article:1805098 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1805098 | pubmed:articleTitle | Inhibition of the Clostridium perfringens phospholipase C hydrolysis of a thiophosphate analog of lysophosphatidylcholine by micelle-bound ammonium and sulfonium cations. | lld:pubmed |
| pubmed-article:1805098 | pubmed:affiliation | Department of Chemistry, University of Illinois, Chicago 60680. | lld:pubmed |
| pubmed-article:1805098 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1805098 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1805098 | lld:pubmed |
