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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-12-4
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pubmed:abstractText |
We screened the Arabidopsis cDNA library to identify functional suppressors of AtBI-1, a gene that suppresses cell death induced by Bax gene expression in yeast. Cdf 3 encodes a 118-amino-acid protein with a molecular mass of 25 kDa. This protein has two uncharacterized domains at amino acids residues 5-64 and 74-117. In the present study, CDF3 was found to induce growth defects in yeast and arrested yeast growth, although the cell-growth defect was somewhat less than that of Bax. Its localization in the inner mitochondria was essential for suppression of yeast-cell proliferation. The morphological abnormality of the intracellular network, which is a hallmark of AtBI-1, was attenuated by Cdf 3 expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1017-7825
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pubmed:author |
pubmed-author:HirataAikoA,
pubmed-author:JunDo-YounDY,
pubmed-author:Kawai-YamadaMakiM,
pubmed-author:KimByung OhBO,
pubmed-author:KimChang-KilCK,
pubmed-author:KimDai-HeeDH,
pubmed-author:KimKyung-MinKM,
pubmed-author:KimSang-KookSK,
pubmed-author:KimYoung-HoYH,
pubmed-author:ParkWanW,
pubmed-author:SohnJae-KeunJK,
pubmed-author:SulIll-WhanIW,
pubmed-author:UchimiyaHirofumiH
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
891-6
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pubmed:meshHeading |
pubmed-meshheading:18050905-Amino Acid Sequence,
pubmed-meshheading:18050905-Apoptosis,
pubmed-meshheading:18050905-Arabidopsis,
pubmed-meshheading:18050905-Arabidopsis Proteins,
pubmed-meshheading:18050905-Base Sequence,
pubmed-meshheading:18050905-Gene Library,
pubmed-meshheading:18050905-Genes, Plant,
pubmed-meshheading:18050905-Membrane Proteins,
pubmed-meshheading:18050905-Mitochondrial Membranes,
pubmed-meshheading:18050905-Molecular Sequence Data,
pubmed-meshheading:18050905-Saccharomyces cerevisiae,
pubmed-meshheading:18050905-bcl-2-Associated X Protein
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pubmed:year |
2007
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pubmed:articleTitle |
Identification of novel mitochondrial membrane protein (Cdf 3) from Arabidopsis thaliana and its functional analysis in a yeast system.
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pubmed:affiliation |
Department of Environmental Horticulture, Sangju National University, Sangfu 742-711, Korea. kkm@sangju.ac.kr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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