Linked Life Data

18050498

Source:http://linkedlifedata.com/resource/pubmed/id/18050498

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-11-30
pubmed:abstractText
Sexual identity is one of a few basic parameters that specify how development should proceed. Although sex determination has profound effects on many tissues, its most ancient and fundamental role is ensuring that some germ cells become sperm, and others become oocytes or eggs. Spermatocytes and oocytes are usually produced in male and female animals, respectively, but C. elegans is uniquely suitable for studying the control of these cell fates because both types of cells are made from a common pool of progenitors in XX hermaphrodites. Extensive genetic and molecular studies have shown that the sexual fate of germ cells in C. elegans is controlled by the same genes that regulate sexual identity in other parts of the animal. However, this regulatory pathway has additional features that are unique to the germ line. First, several genes, like the three fogs, act only in germ cells. Second, the three fem genes act in concert with targets of tra-1 to control germ cell fates, but do not act this way in the soma. Third, translational repression of tra-2 is essential for hermaphrodite spermatogenesis. Fourth, translational repression of fem-3 is needed for oogenesis. In this review, we present genetic and molecular models for how these processes work, and summarize the evidence upon which they are built.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1551-8507
pubmed:author
pubmed:issnType
Electronic
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-13
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Sex determination in the germ line.
pubmed:affiliation
Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford, NJ 08084, USA. ron.ellis@umdnj.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural