Source:http://linkedlifedata.com/resource/pubmed/id/18050297
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
2008-2-13
|
pubmed:abstractText |
The intestinal epithelium is a single layer of polarized cells and is the primary barrier separating foreign antigen and underlying lymphoid tissue. IFNgamma alters epithelial barrier function during inflammation by disrupting tight cell junctions and facilitating the paracellular transport of luminal antigens. The aim of this work was to determine whether Campylobacter infection of cells exposed to IFNgamma would lead to greater disruption of cell monolayers and hence increased bacterial translocation.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
1078-0998
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
303-9
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:18050297-Actins,
pubmed-meshheading:18050297-Apoptosis,
pubmed-meshheading:18050297-Bacterial Translocation,
pubmed-meshheading:18050297-Caco-2 Cells,
pubmed-meshheading:18050297-Campylobacter Infections,
pubmed-meshheading:18050297-Campylobacter jejuni,
pubmed-meshheading:18050297-Cell Membrane Permeability,
pubmed-meshheading:18050297-Epithelium,
pubmed-meshheading:18050297-Humans,
pubmed-meshheading:18050297-Interferon-gamma,
pubmed-meshheading:18050297-Intestinal Mucosa,
pubmed-meshheading:18050297-Membrane Potentials,
pubmed-meshheading:18050297-Membrane Proteins,
pubmed-meshheading:18050297-Microscopy, Fluorescence
|
pubmed:year |
2008
|
pubmed:articleTitle |
Campylobacter and IFNgamma interact to cause a rapid loss of epithelial barrier integrity.
|
pubmed:affiliation |
Division of Veterinary Pathology, Infection and Immunity, School of Clinical Veterinary Science, University of Bristol, Bristol, UK.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|