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rdf:type |
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lifeskim:mentions |
umls-concept:C0016030,
umls-concept:C0024109,
umls-concept:C0040690,
umls-concept:C0079284,
umls-concept:C0086418,
umls-concept:C0127400,
umls-concept:C0871261,
umls-concept:C1363844,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
12
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pubmed:dateCreated |
2007-12-17
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pubmed:abstractText |
Fibrosis is excessive scarring caused by the accumulation and contraction of extracellular matrix proteins and is a common end pathway in many chronic diseases, including scleroderma (systemic sclerosis [SSc]). Indeed, pulmonary fibrosis is a major cause of death in SSc. Transforming growth factor beta (TGFbeta) induces endothelin 1 (ET-1) in human lung fibroblasts by a Smad-independent, JNK-dependent mechanism. The goal of this study was to assess whether ET-1 is a downstream mediator of the profibrotic effects of TGFbeta in lung fibroblasts.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTGF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Connective Tissue Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Fibronectins,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Endothelin,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/bosentan
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4189-94
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18050250-Cells, Cultured,
pubmed-meshheading:18050250-Collagen Type I,
pubmed-meshheading:18050250-Connective Tissue Growth Factor,
pubmed-meshheading:18050250-Endothelin-1,
pubmed-meshheading:18050250-Extracellular Matrix,
pubmed-meshheading:18050250-Fibroblasts,
pubmed-meshheading:18050250-Fibronectins,
pubmed-meshheading:18050250-Gene Expression Profiling,
pubmed-meshheading:18050250-Humans,
pubmed-meshheading:18050250-Immediate-Early Proteins,
pubmed-meshheading:18050250-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:18050250-Lung,
pubmed-meshheading:18050250-Phenotype,
pubmed-meshheading:18050250-Pulmonary Fibrosis,
pubmed-meshheading:18050250-Receptors, Endothelin,
pubmed-meshheading:18050250-Sulfonamides,
pubmed-meshheading:18050250-Transforming Growth Factor beta
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pubmed:year |
2007
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pubmed:articleTitle |
Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.
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pubmed:affiliation |
Royal Free Hospital, University College London, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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