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rdf:type |
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lifeskim:mentions |
umls-concept:C0021753,
umls-concept:C0033640,
umls-concept:C0037083,
umls-concept:C0079904,
umls-concept:C0086418,
umls-concept:C0132555,
umls-concept:C0205225,
umls-concept:C0205263,
umls-concept:C0225369,
umls-concept:C0332307,
umls-concept:C1314939,
umls-concept:C1412209,
umls-concept:C1710082
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pubmed:issue |
12
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pubmed:dateCreated |
2007-12-17
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pubmed:abstractText |
Protein kinase Czeta (PKCzeta), an atypical PKC, has been found to be transcriptionally up-regulated in human osteoarthritic (OA) articular cartilage. This study was undertaken to examine the role of PKCzeta in interleukin-1beta (IL-1beta)-induced NF-kappaB signaling in human OA chondrocytes, and ultimately to better understand its function in the regulation of downstream mediators of cartilage matrix degradation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADAM Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Procollagen N-Endopeptidase,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/aggrecanase,
http://linkedlifedata.com/resource/pubmed/chemical/aggrecanase-1,
http://linkedlifedata.com/resource/pubmed/chemical/protein kinase C zeta
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4074-83
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pubmed:dateRevised |
2009-4-7
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pubmed:meshHeading |
pubmed-meshheading:18050214-ADAM Proteins,
pubmed-meshheading:18050214-Cells, Cultured,
pubmed-meshheading:18050214-Chondrocytes,
pubmed-meshheading:18050214-Endopeptidases,
pubmed-meshheading:18050214-Humans,
pubmed-meshheading:18050214-Interleukin-1beta,
pubmed-meshheading:18050214-NF-kappa B,
pubmed-meshheading:18050214-Nitric Oxide,
pubmed-meshheading:18050214-Nitric Oxide Synthase Type II,
pubmed-meshheading:18050214-Osteoarthritis,
pubmed-meshheading:18050214-Phosphorylation,
pubmed-meshheading:18050214-Procollagen N-Endopeptidase,
pubmed-meshheading:18050214-Protein Kinase C,
pubmed-meshheading:18050214-RNA, Messenger,
pubmed-meshheading:18050214-Signal Transduction
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pubmed:year |
2007
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pubmed:articleTitle |
Involvement of protein kinase Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes.
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pubmed:affiliation |
Department of Women's Health and Musculoskeletal Biology, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA. pchockalinga@wyeth.com
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pubmed:publicationType |
Journal Article
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