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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-12-17
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pubmed:abstractText |
In classic studies on the genetic background of antibody production, the major histocompatibility complex (MHC) has been shown to act as the most prominent immune response gene that controls the magnitude and the specificity of antibody production. The strongest genetic risk factor for rheumatoid arthritis (RA), the human MHC HLA-DRB1 shared epitope (SE) alleles, predisposes for antibodies against citrullinated proteins (ACPAs). ACPA levels are higher in SE-positive patients with RA than in SE-negative patients with RA. The aim of the present study was to determine whether SE influences not only the magnitude but also the specificity of the ACPA response.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0004-3591
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pubmed:author |
pubmed-author:AllaartC FCF,
pubmed-author:BreedveldF CFC,
pubmed-author:CheungKK,
pubmed-author:DrijfhoutJ WJW,
pubmed-author:HuizingaT W JTW,
pubmed-author:Ioan-FacsinayAA,
pubmed-author:PruijnG J MGJ,
pubmed-author:ToesR E MRE,
pubmed-author:VerpoortK NKN,
pubmed-author:de Vries-BouwstraJ KJK,
pubmed-author:de VriesR R PRR,
pubmed-author:van der Helm-van MilA H MAH
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3949-52
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18050209-Alleles,
pubmed-meshheading:18050209-Antibodies, Anti-Idiotypic,
pubmed-meshheading:18050209-Antibody Specificity,
pubmed-meshheading:18050209-Arthritis, Rheumatoid,
pubmed-meshheading:18050209-Citrulline,
pubmed-meshheading:18050209-Cohort Studies,
pubmed-meshheading:18050209-Epitopes,
pubmed-meshheading:18050209-Fibrinogen,
pubmed-meshheading:18050209-Genetic Predisposition to Disease,
pubmed-meshheading:18050209-HLA-DR Antigens,
pubmed-meshheading:18050209-HLA-DRB1 Chains,
pubmed-meshheading:18050209-Humans,
pubmed-meshheading:18050209-Vimentin
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pubmed:year |
2007
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pubmed:articleTitle |
Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles.
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pubmed:affiliation |
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. K.N.Verpoort@lumc.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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