18049466

Source:http://linkedlifedata.com/resource/pubmed/id/18049466

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0542341, umls-concept:C1113686, umls-concept:C1510464
pubmed:issue	12
pubmed:dateCreated	2007-11-30
pubmed:abstractText	To characterize the contributions of individual amino acids to the structure or function of a protein, researchers have adopted directed evolution approaches, which use iterated cycles of mutagenesis and selection or screening to search vast areas of sequence space for sets of mutations that provide insights into the protein of interest.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101215604
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Proteins
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	1548-7105
pubmed:author	pubmed-author:LiuDavid RDR, pubmed-author:YuenCourtney MCM
pubmed:issnType	Electronic
pubmed:volume	4
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	995-7
pubmed:meshHeading	pubmed-meshheading:18049466-Directed Molecular Evolution, pubmed-meshheading:18049466-Evolution, Molecular, pubmed-meshheading:18049466-Mutagenesis, Site-Directed, pubmed-meshheading:18049466-Protein Engineering, pubmed-meshheading:18049466-Proteins, pubmed-meshheading:18049466-Structure-Activity Relationship
pubmed:year	2007
pubmed:articleTitle	Dissecting protein structure and function using directed evolution.
pubmed:affiliation	Howard Hughes Medical Institute and Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't