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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-3-17
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pubmed:abstractText |
Inflammatory bowel disease (IBD)--Crohn's disease (CD) and ulcerative colitis (UC)--and celiac disease are intestinal inflammatory disorders with a complex genetic background. Recently, two novel genes were found to be associated with IBD susceptibility. One, an uncommon coding variant (rs11209026) in the gene encoding for the interleukin-23 receptor (IL23R), conferred strong protection against CD. The other, rs2241880 in the autophagy-related 16-like 1 gene (ATG16L1), was associated with CD. We performed a case-control study for the association of IBD with IL23R and ATG16L1 in a Dutch cohort. We also looked at the association of IL23R and ATG16L1 with celiac disease.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0002-9270
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
621-7
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pubmed:meshHeading |
pubmed-meshheading:18047540-Adolescent,
pubmed-meshheading:18047540-Adult,
pubmed-meshheading:18047540-Aged,
pubmed-meshheading:18047540-Carrier Proteins,
pubmed-meshheading:18047540-Case-Control Studies,
pubmed-meshheading:18047540-Celiac Disease,
pubmed-meshheading:18047540-Child,
pubmed-meshheading:18047540-Colitis, Ulcerative,
pubmed-meshheading:18047540-Crohn Disease,
pubmed-meshheading:18047540-Female,
pubmed-meshheading:18047540-Genetic Markers,
pubmed-meshheading:18047540-Genetic Predisposition to Disease,
pubmed-meshheading:18047540-Genotype,
pubmed-meshheading:18047540-Humans,
pubmed-meshheading:18047540-Male,
pubmed-meshheading:18047540-Middle Aged,
pubmed-meshheading:18047540-Netherlands,
pubmed-meshheading:18047540-Polymorphism, Single Nucleotide,
pubmed-meshheading:18047540-Receptors, Interleukin
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pubmed:year |
2008
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pubmed:articleTitle |
ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands.
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pubmed:affiliation |
Department of Gastroenterology and Hepatology, University Medical Center Groningen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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