Linked Life Data

18047289

Source:http://linkedlifedata.com/resource/pubmed/id/18047289

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-1-14
pubmed:abstractText
There is much interest in the development of a nanoscale drug delivery system with MRI visibility to optimize the delivery efficiency and therapeutic efficacy under image guidance. Here we report on the successful fabrication of nanoscale micelles based on biodegradable poly( L-glutamic acid)- b-polylactide (PG- b-PLA) block copolymer with paramagnetic Gd3+ ions chelated to their shell. PG- b-PLA was synthesized by sequential polymerization reactions: anionic polymerization of L-lactide followed by ring-opening polymerization of benzyl glutamate N-carboxylic anhydride. The metal chelator p-aminobenzyldiethylenetriaminepenta(acetic acid) (DTPA) was readily conjugated to the side chain carboxylic acids of poly( L-glutamic acid). The resulting copolymer formed spherical micelles in aqueous solution with an average diameter of 230 nm at pH 7.4. The size of PG(DTPA)- b-PLA micelles decreased with increasing pH value. DTPA-Gd chelated to the shell layer of the micelles exhibited significantly higher spin-lattice relaxivity (r1) than a small-molecular-weight MRI contrast agent, indicating that water molecules could readily access the Gd ions in the micelles. Because of the presence of multiple carboxylic acid functional groups in the shell layer, polymeric micelles based on biodegradable PG(DTPA-Gd)- b-PLA may be a suitable platform for the development of MRI-visible, targeted nanoscale drug delivery systems.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-11251249, http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-11897148, http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-12203012, http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-12204599, http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-14680253, http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-15012139, http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-15762635, http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-16450332, http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-17090068, http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-1743920, http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-2039998, http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-3786763, http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-8121264, http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-8730968, http://linkedlifedata.com/resource/pubmed/commentcorrection/18047289-9389476
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1526-4602
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
36-42
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Micelles based on biodegradable poly(L-glutamic acid)-b-polylactide with paramagnetic Gd ions chelated to the shell layer as a potential nanoscale MRI-visible delivery system.
pubmed:affiliation
Department of Experimental Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural