18045470

Source:http://linkedlifedata.com/resource/pubmed/id/18045470

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006141, umls-concept:C0008976, umls-concept:C0034656, umls-concept:C0221198, umls-concept:C0302350, umls-concept:C0348026, umls-concept:C1114599, umls-concept:C1274040, umls-concept:C2603343
pubmed:dateCreated	2008-2-1
pubmed:abstractText	BACKGROUND: In recent years there has been an increasing interest in MRI as a non-invasive diagnostic modality for the work-up of suspicious breast lesions. The additional value of Breast MRI lies mainly in its capacity to detect multicentric and multifocal disease, to detect invasive components in ductal carcinoma in situ lesions and to depict the tumor in a 3-dimensional image. Breast MRI therefore has the potential to improve the diagnosis and provide better preoperative staging and possibly surgical care in patients with breast cancer. The aim of our study is to assess whether performing contrast enhanced Breast MRI can reduce the number of surgical procedures due to better preoperative staging and whether a subgroup of women with suspicious nonpalpable breast lesions can be identified in which the combination of mammography, ultrasound and state-of-the-art contrast-enhanced Breast MRI can provide a definite diagnosis. METHODS/DESIGN: The MONET - study (MR mammography Of Nonpalpable BrEast Tumors) is a randomized controlled trial with diagnostic and therapeutic endpoints. We aim to include 500 patients with nonpalpable suspicious breast lesions who are referred for biopsy. With this number of patients, the expected 12% reduction in surgical procedures due to more accurate preoperative staging with Breast MRI can be detected with a high power (90%). The secondary outcome is the positive and negative predictive value of contrast enhanced Breast MRI. If the predictive values are deemed sufficiently close to those for large core biopsy then the latter, invasive, procedure could possibly be avoided in some women. The rationale, study design and the baseline characteristics of the first 100 included patients are described. TRIAL REGISTRATION: Study protocol number NCT00302120.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-10410164, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-10580970, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-10663717, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-10845808, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-11250746, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-11382949, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-12438043, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-12734086, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-12764634, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-12879462, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-14570948, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-14654471, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-15135477, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-15248080, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-15319568, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-15385322, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-16514137, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-18024435, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-7480749, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-9242745, http://linkedlifedata.com/resource/pubmed/commentcorrection/18045470-9477265
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101263253
pubmed:status	PubMed-not-MEDLINE
pubmed:issn	1745-6215
pubmed:author	pubmed-author:Borel RinkesInne H MIH, pubmed-author:MaliWillem P T MWP, pubmed-author:PeetersPetra H MPH, pubmed-author:PetersNicky H G MNH, pubmed-author:PlaisierPeter WPW, pubmed-author:StormRemmert KRK, pubmed-author:de BoerErwinE, pubmed-author:van OverbeekeAdriaan JAJ, pubmed-author:van den BoschMaurice A A JMA
pubmed:issnType	Electronic
pubmed:volume	8
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	40
pubmed:year	2007
pubmed:articleTitle	Breast MRI in nonpalpable breast lesions: a randomized trial with diagnostic and therapeutic outcome - MONET - study.
pubmed:affiliation	Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands. n.peters@umcutrecht.nl
pubmed:publicationType	Journal Article