Linked Life Data

18045194

Source:http://linkedlifedata.com/resource/pubmed/id/18045194

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
33
pubmed:dateCreated
2007-11-29
pubmed:abstractText
Nuclear factor-kappaBeta (NF-kappaBeta) is a transcription factor that is activated in response to various inflammatory stimuli such as cytokines, growth factors, hormones, mitogens, carcinogens, chemotherapeutic agents, viral products, eukaryotic parasites, endotoxin, fatty acids, metals, radiation, hypoxia, and psychological, physical, oxidative, and chemical stresses. In addition, constitutively active NF-kappaBeta is frequently encountered in a wide variety of tumors. Furthermore, NF-kappaBeta activation has been shown to regulate the expression of over 400 genes involved in cellular transformation, proliferation, inflammation, viral replication, antiapoptosis, angiogenesis, invasion and metastasis, oxidative stress, and osteoclastogenesis. Therefore, because of the critical role NF-kappaBeta plays in the pathogenesis of cancer, specific inhibitors of this factor are being sought. Agents that prevent cancer or inflammation have been found to suppress NF-kappaBeta activation. Numerous reports indicate that ancient plants and their components are potent as NF-kappaB inibitors. However, ancient medicine such as traditional Chinese medicine, Kampo, Ayurveda requires rediscovery in light of our current knowledge of allopathic (modern) medicine for the therapeutic and preventive purpose. In this review, we present evidence that numerous agents identified from fruits and vegetables can interfere with NF-kappaBeta pathway. The structure of drugs and their relationship with NF-kappaBeta inhibitory activity is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1873-4286
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3400-16
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Anticancer drugs designed by mother nature: ancient drugs but modern targets.
pubmed:affiliation
International Research and Educational Institute for Integrated Medical Sciences (IREIIMS), Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
pubmed:publicationType
Journal Article, Review