Source:http://linkedlifedata.com/resource/pubmed/id/18045151
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2007-11-29
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| pubmed:abstractText |
Thyroid hormones (THs) have a relevant action on brain development and maintenance. By using an acute treatment to induce a hyperthyroid animal model, we aimed at investigating the effect of an altered THs levels on learning and memory and on the activity of Na(+), K(+)-ATPase in the rat brain. Our results have shown that the acute treatment with L-T4 did not alter the retrieval of the inhibitory avoidance task, but had a significant effect on the elevated plus maze and on open-field performance in rats. We suggest that animals subjected to L-T4 administration improved the habituation to a novel environment as well as a better evaluation of a dangerous environment, respectively. Na(+), K(+)-ATPase activity is increased in parietal cortex (30%), but it is not altered in hippocampus in L-T4 treated group. These both brain structures are involved in memory processing and it was previously demonstrated that there is a double dissociation between them for spatial location information, perceptual and episodic memory. We propose the hypothesis that this increase of Na(+), K(+)-ATPase activity in parietal cortex may be correlated to our results in behavior tests, which suggest a role of THs as well as of the Na(+), K(+)-ATPase in the cognitive process.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
|
| pubmed:issn |
1567-2026
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| pubmed:author |
pubmed-author:BavarescoCarenC,
pubmed-author:CastroCibele CanalCC,
pubmed-author:CoitinhoAdriana SimonAS,
pubmed-author:IzquierdoIvánI,
pubmed-author:PerrenoudMyriam FortesMF,
pubmed-author:RamirezMaria RosanaMR,
pubmed-author:SarkisJoão José FreitasJJ,
pubmed-author:WyseAngela Terezinha de SouzaAT,
pubmed-author:da TrindadeLaura Schumacher SchuhLS,
pubmed-author:dos Reis-LunardelliEleonora AraújoEA
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| pubmed:issnType |
Print
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| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
259-67
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| pubmed:meshHeading |
pubmed-meshheading:18045151-Animals,
pubmed-meshheading:18045151-Anxiety,
pubmed-meshheading:18045151-Avoidance Learning,
pubmed-meshheading:18045151-Behavior, Animal,
pubmed-meshheading:18045151-Body Weight,
pubmed-meshheading:18045151-Brain,
pubmed-meshheading:18045151-Habituation, Psychophysiologic,
pubmed-meshheading:18045151-Hippocampus,
pubmed-meshheading:18045151-Male,
pubmed-meshheading:18045151-Memory,
pubmed-meshheading:18045151-Motor Activity,
pubmed-meshheading:18045151-Parietal Lobe,
pubmed-meshheading:18045151-Rats,
pubmed-meshheading:18045151-Rats, Wistar,
pubmed-meshheading:18045151-Risk-Taking,
pubmed-meshheading:18045151-Sodium-Potassium-Exchanging ATPase,
pubmed-meshheading:18045151-Synaptic Membranes,
pubmed-meshheading:18045151-Thyroid Hormones,
pubmed-meshheading:18045151-Thyroxine
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| pubmed:year |
2007
|
| pubmed:articleTitle |
Effects of an acute treatment with L-thyroxine on memory, habituation, danger avoidance, and on Na+, K+ -ATPase activity in rat brain.
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| pubmed:affiliation |
Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. reis.lunardelli@gmail.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|