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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-2-4
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pubmed:abstractText |
We investigated whether telomere length was associated with the risk of Parkinson's disease (PD) in a case-control study (96 cases and 172 age-matched controls) nested within the Health Professionals Follow-up Study. Relative ratio of telomere repeat copy number to single-gene copy number in peripheral blood leukocytes was determined by quantitative real time PCR. Men with shorter telomeres had a lower PD risk (multivariate adjusted relative risk for the lowest vs. the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-11456310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-11761476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-11976182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-12000852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-12114022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-12493553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-12573379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-14511933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-14732735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-15031734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-16112303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-16539655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-16685698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-1678444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-16807921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-1708110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18044760-7787596
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1531-8257
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pubmed:author |
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pubmed:copyrightInfo |
2007 Movement Disorder Society
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
302-5
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pubmed:dateRevised |
2011-4-5
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pubmed:meshHeading |
pubmed-meshheading:18044760-Adult,
pubmed-meshheading:18044760-Aged,
pubmed-meshheading:18044760-Case-Control Studies,
pubmed-meshheading:18044760-Follow-Up Studies,
pubmed-meshheading:18044760-Humans,
pubmed-meshheading:18044760-Male,
pubmed-meshheading:18044760-Middle Aged,
pubmed-meshheading:18044760-Parkinson Disease,
pubmed-meshheading:18044760-Retrospective Studies,
pubmed-meshheading:18044760-Risk Factors,
pubmed-meshheading:18044760-Telomere
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pubmed:year |
2008
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pubmed:articleTitle |
Telomere length and risk of Parkinson's disease.
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pubmed:affiliation |
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. hwangi@hsph.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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