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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1992-5-7
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pubmed:abstractText |
Ultraviolet (UV) irradiation is capable of producing a dose-dependent decomposition of skin surface lipids and particularly of squalene, with the concomitant generation of active lipoperoxides. The biological effects of UV-peroxidated squalene were tested, compared with those produced by synthetic lipoperoxides (cumene hydroperoxide), on some immunological parameters in vivo modified by UVB irradiation. Application of UV-peroxidated squalene as well as cumene hydroperoxide significantly inhibited the induction of contact hypersensitivity to dinitrofluorobenzene in mice, which was associated with a decrease in the number of ATPase positive cells. The effect was dose-dependent (over 40 micrograms for peroxidated squalene and over 20 micrograms for cumene) and relevant after 2 d of treatment. Down-regulation towards the applied hapten was demonstrated. The results indicate that UV-induced lipoperoxides of squalene are capable of inhibiting the induction of contact hypersensitivity in mice and suggest that, among the other photoproducts generated in humans, squalene peroxides may play a role as biochemical messengers of the biological effects of UV irradiation of the skin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0905-4383
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1804289-Animals,
pubmed-meshheading:1804289-Benzene Derivatives,
pubmed-meshheading:1804289-Dermatitis, Contact,
pubmed-meshheading:1804289-Dose-Response Relationship, Radiation,
pubmed-meshheading:1804289-Male,
pubmed-meshheading:1804289-Mice,
pubmed-meshheading:1804289-Mice, Inbred C3H,
pubmed-meshheading:1804289-Skin,
pubmed-meshheading:1804289-Squalene,
pubmed-meshheading:1804289-Ultraviolet Rays
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pubmed:year |
1991
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pubmed:articleTitle |
Squalene peroxides may contribute to ultraviolet light-induced immunological effects.
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pubmed:affiliation |
Istituto Dermatologico San Gallicano, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study
|