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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-3-17
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pubmed:abstractText |
Directional cell migration is a fundamental feature of embryonic development, the inflammatory response and the metastatic spread of cancer. Migrating cells have a polarized morphology with an asymmetric distribution of signalling molecules and of the actin and microtubule cytoskeletons. The dynamic reorganization of the actin cytoskeleton provides the major driving force for migration in all mammalian cell types, but microtubules also play an important role in many cells, most notably neuronal precursors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1768-322X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
243-52
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pubmed:meshHeading |
pubmed-meshheading:18042042-Adenomatous Polyposis Coli,
pubmed-meshheading:18042042-Adenomatous Polyposis Coli Protein,
pubmed-meshheading:18042042-Animals,
pubmed-meshheading:18042042-Astrocytes,
pubmed-meshheading:18042042-Cell Culture Techniques,
pubmed-meshheading:18042042-Cell Movement,
pubmed-meshheading:18042042-Cell Polarity,
pubmed-meshheading:18042042-Centrosome,
pubmed-meshheading:18042042-Fibroblasts,
pubmed-meshheading:18042042-HeLa Cells,
pubmed-meshheading:18042042-Humans,
pubmed-meshheading:18042042-Microscopy, Confocal,
pubmed-meshheading:18042042-Microtubules,
pubmed-meshheading:18042042-Neurons,
pubmed-meshheading:18042042-Nuclear Envelope,
pubmed-meshheading:18042042-Nuclear Pore,
pubmed-meshheading:18042042-Nuclear Pore Complex Proteins,
pubmed-meshheading:18042042-Rats,
pubmed-meshheading:18042042-Sequence Deletion
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pubmed:year |
2008
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pubmed:articleTitle |
APC nuclear membrane association and microtubule polarity.
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pubmed:affiliation |
MRC Laboratory for Molecular Cell Biology, Cancer Research UK Oncogene and Signal Transduction Group and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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