Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1992-4-28
pubmed:abstractText
The present paper reports the modulatory influence of two widely used combined oral contraceptive pills "OVRAL" and "NORACYCLINE" on hepatic phase I and II drug metabolizing enzymes and acid soluble sulfhydryl group of the mouse. Three different doses of the pills were used in this study i.e. D1 (1/2000th of a pill), D2 (1/200th of a pill) and D3 (1/20th of a pill). The sulfhydryl group increased significantly with the D1 and D2 dose of Ovral and the D2 dose of Noracycline. Dose D2 of both pills decreased cyt.P450 and cyt.b5 contents. D3 of Noracycline, however increased both the cytochrome levels. Dose D3 of Ovral and all three doses of Noracycline reduced the glutathione S-transferase activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Contraceptives, Oral, Combined, http://linkedlifedata.com/resource/pubmed/chemical/Contraceptives, Oral, Hormonal, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System, http://linkedlifedata.com/resource/pubmed/chemical/Cytochromes b5, http://linkedlifedata.com/resource/pubmed/chemical/Ethinyl Estradiol, http://linkedlifedata.com/resource/pubmed/chemical/Ethinyl Estradiol-Norgestrel..., http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase, http://linkedlifedata.com/resource/pubmed/chemical/Lynestrenol, http://linkedlifedata.com/resource/pubmed/chemical/Mestranol, http://linkedlifedata.com/resource/pubmed/chemical/Noracycline, http://linkedlifedata.com/resource/pubmed/chemical/Norgestrel, http://linkedlifedata.com/resource/pubmed/chemical/Sulfhydryl Compounds
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0158-5231
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
973-84
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1804114-Animals, pubmed-meshheading:1804114-Biotransformation, pubmed-meshheading:1804114-Contraceptives, Oral, Combined, pubmed-meshheading:1804114-Contraceptives, Oral, Hormonal, pubmed-meshheading:1804114-Cytochrome P-450 Enzyme System, pubmed-meshheading:1804114-Cytochromes b5, pubmed-meshheading:1804114-Dose-Response Relationship, Drug, pubmed-meshheading:1804114-Enzyme Activation, pubmed-meshheading:1804114-Ethinyl Estradiol, pubmed-meshheading:1804114-Ethinyl Estradiol-Norgestrel Combination, pubmed-meshheading:1804114-Female, pubmed-meshheading:1804114-Glutathione Transferase, pubmed-meshheading:1804114-Lynestrenol, pubmed-meshheading:1804114-Mestranol, pubmed-meshheading:1804114-Metabolic Detoxication, Drug, pubmed-meshheading:1804114-Mice, pubmed-meshheading:1804114-Microsomes, Liver, pubmed-meshheading:1804114-Norgestrel, pubmed-meshheading:1804114-Sulfhydryl Compounds
pubmed:year
1991
pubmed:articleTitle
Effects of oral contraceptive pills on drug metabolizing enzymes and acid soluble sulfhydryl level in mouse liver.
pubmed:affiliation
Department of Carcinogenesis, Institut Suisse De Recherches Experimentales Sur Le Cancer, Lausanne.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't