Source:http://linkedlifedata.com/resource/pubmed/id/18039929
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2008-4-1
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pubmed:abstractText |
Mitogen-activated protein kinase (MAPK) pathways constitute a large modular network that regulates a variety of physiological processes, such as cell growth, differentiation, and apoptotic cell death. The function of the ERK pathway has been depicted as survival-promoting, in essence by opposing the proapoptotic activity of the stress-activated c-Jun NH(2)-terminal kinase (JNK)/p38 MAPK pathways. However, recently published work suggests that extracellular regulated kinase (ERK) pathway activity is suppressed by JNK/p38 kinases during apoptosis induction. In this review, we will summarize the current knowledge about JNK/p38-mediated mechanisms that negatively regulate the ERK pathway. In particular, we will focus on phosphatases (PP2A, MKPs) as inhibitors of ERK pathway activity in regulating apoptosis. A model proposed in this review places the negative regulation of the ERK pathway in a central position for the cellular decision-making process that determines whether cells will live or die in response to apoptosis-promoting signals. In addition, we will discuss the potential functional relevance of negative regulation of ERK pathway activity, for physiological and pathological conditions (e.g., cellular transformation).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1530-6860
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
954-65
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18039929-Animals,
pubmed-meshheading:18039929-Cell Survival,
pubmed-meshheading:18039929-Humans,
pubmed-meshheading:18039929-MAP Kinase Signaling System,
pubmed-meshheading:18039929-Mitogen-Activated Protein Kinases,
pubmed-meshheading:18039929-Models, Biological,
pubmed-meshheading:18039929-Phosphoprotein Phosphatases
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pubmed:year |
2008
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pubmed:articleTitle |
Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival.
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pubmed:affiliation |
Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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