Source:http://linkedlifedata.com/resource/pubmed/id/18039895
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions |
umls-concept:C0012984,
umls-concept:C0017262,
umls-concept:C0078058,
umls-concept:C0148199,
umls-concept:C0185117,
umls-concept:C0332281,
umls-concept:C0349658,
umls-concept:C0431085,
umls-concept:C0553723,
umls-concept:C0596290,
umls-concept:C0597032,
umls-concept:C1171892,
umls-concept:C1441616,
umls-concept:C2911684
|
pubmed:issue |
6
|
pubmed:dateCreated |
2007-11-27
|
pubmed:abstractText |
The expression of 5 markers associated with angiogenesis was studied in canine squamous cell carcinomas (SCCs) (n = 19) and canine trichoepitheliomas (TCPs) (n = 24). SCCs were assigned histologic grades, and tissue sections from both tumor types were immunohistochemially stained for the expression of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2 (VEGFR-2), as well as intratumoral microvessel density (iMVD), tumor proliferation index (PI), and tumor apoptotic index (AI), using antibodies against VEGF, VEGFR-2, von Willebrand's factor, Ki-67 antigen, and the terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate end-labeling method (TUNEL), respectively. VEGF and VEGFR-2 were detected in 17/19 (89.4%) and 19/19 (100%) SCCs and in 17/24 (70.8%) and 20/24 (83.3%) TCPs, respectively. In SCCs, there was substantial correlation between histologic grade and PI (r = 0.51); and moderate correlation between VEGF and histologic grade (r = 0.43), VEGFR-2 and histologic grade (r = 0.47), VEGF and PI (r = 0.47), and VEGFR-2 and PI (r = 0.47) (Spearman rank correlation coefficient). In TCPs, there was substantial correlation between VEGF and PI (r = 0.51) and a moderate correlation between VEGFR-2 and iMVD (r = 0.36). The median iMVD of SCCs (15.5) was significantly higher than the median iMVD of TCPs (9.05) (P value < .05). It was concluded that VEGF and VEGFR-2 may promote tumor cell proliferation in TCPs and SCCs. An autocrine pathway for VEGF probably operates in canine SCCs and TCPs, as VEGF and VEGFR-2 expression was found in most tumors and was associated with evidence for tumor cell proliferation.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Vascular Endothelial...,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/von Willebrand Factor
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0300-9858
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
44
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
823-30
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:18039895-Animals,
pubmed-meshheading:18039895-Biological Markers,
pubmed-meshheading:18039895-Carcinoma,
pubmed-meshheading:18039895-Carcinoma, Squamous Cell,
pubmed-meshheading:18039895-Cell Proliferation,
pubmed-meshheading:18039895-Dog Diseases,
pubmed-meshheading:18039895-Dogs,
pubmed-meshheading:18039895-Gene Expression Regulation,
pubmed-meshheading:18039895-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18039895-Immunohistochemistry,
pubmed-meshheading:18039895-Ki-67 Antigen,
pubmed-meshheading:18039895-Neovascularization, Pathologic,
pubmed-meshheading:18039895-Receptors, Vascular Endothelial Growth Factor,
pubmed-meshheading:18039895-Vascular Endothelial Growth Factor A,
pubmed-meshheading:18039895-von Willebrand Factor
|
pubmed:year |
2007
|
pubmed:articleTitle |
Immunohistochemical expression of vascular endothelial growth factor and vascular endothelial growth factor receptor associated with tumor cell proliferation in canine cutaneous squamous cell carcinomas and trichoepitheliomas.
|
pubmed:affiliation |
Department of Veterinary Pathology, Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|