Linked Life Data

18039009

Source:http://linkedlifedata.com/resource/pubmed/id/18039009

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2007-12-28
pubmed:abstractText
Five new ecdysteroids, hyousterones A-D (2-5) and abeohyousterone (6), have been isolated from the Antarctic tunicate Synoicum adareanum along with the known ecdysteroid diaulusterol B (1). Hyousterones B (3) and D (5) are unusual ecdysteroids in bearing the 14beta-hydroxyl group, and abeohyousterone incorporates the 13(14-->8) abeo steroid skeleton, reflecting a rearrangement of the steroid C/D ring system. Abeohyousterone has moderate cytotoxicity toward several cancer cell lines. Hyousterones bearing the 14alpha-hydroxy group (2 and 4) were weakly cytotoxic, while the 14beta-hydroxy hyousterones (3 and 5) were devoid of cytotoxicity. The 14beta-hydroxy function may be a thermodynamic pathway to the 13(14-->8) abeo steroid skeleton. Hyousterones, abeohyousterone, and diaulusterol B are the first ecdysteroids reported from tunicates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0163-3864
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1859-64
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Ecdysteroids from the Antarctic tunicate Synoicum adareanum.
pubmed:affiliation
Department of Chemistry and Center for Molecular Diversity in Drug Design, Discovery, and Delivery, University of South Florida, Tampa, FL 33620, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.