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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-12-7
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pubmed:abstractText |
The serine-threonine kinases Pim-1 and Akt regulate cellular proliferation and survival. Although Akt is known to be a crucial signaling protein in the myocardium, the role of Pim-1 has been overlooked. Pim-1 expression in the myocardium of mice decreased during postnatal development, re-emerged after acute pathological injury in mice and was increased in failing hearts of both mice and humans. Cardioprotective stimuli associated with Akt activation induced Pim-1 expression, but compensatory increases in Akt abundance and phosphorylation after pathological injury by infarction or pressure overload did not protect the myocardium in Pim-1-deficient mice. Transgenic expression of Pim-1 in the myocardium protected mice from infarction injury, and Pim-1 expression inhibited cardiomyocyte apoptosis with concomitant increases in Bcl-2 and Bcl-X(L) protein levels, as well as in Bad phosphorylation levels. Relative to nontransgenic controls, calcium dynamics were significantly enhanced in Pim-1-overexpressing transgenic hearts, associated with increased expression of SERCA2a, and were depressed in Pim-1-deficient hearts. Collectively, these data suggest that Pim-1 is a crucial facet of cardioprotection downstream of Akt.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1546-170X
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pubmed:author |
pubmed-author:AlvarezRobertoR,
pubmed-author:AnversaPieroP,
pubmed-author:ArcareseMichaelM,
pubmed-author:BerettaRemus MRM,
pubmed-author:BernsAntonA,
pubmed-author:CottageChristopherC,
pubmed-author:DelucchiFrancescaF,
pubmed-author:EmmanuelGregory NGN,
pubmed-author:EspositoGraziaG,
pubmed-author:FischerKimberleeK,
pubmed-author:FransioliJennaJ,
pubmed-author:GlembotskiChristopher CCC,
pubmed-author:GudeNatalieN,
pubmed-author:HouserSteven RSR,
pubmed-author:KajsturaJanJ,
pubmed-author:LeriAnnarosaA,
pubmed-author:MagnusonNancyN,
pubmed-author:MartindaleJoshua JJJ,
pubmed-author:MisaoYuY,
pubmed-author:MuraskiJohn AJA,
pubmed-author:RotaMarcelloM,
pubmed-author:SchaeferErik MEM,
pubmed-author:SiddiqiSailayS,
pubmed-author:SussmanMark AMA,
pubmed-author:WuWeitaoW
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pubmed:issnType |
Electronic
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1467-75
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18037896-Animals,
pubmed-meshheading:18037896-Apoptosis,
pubmed-meshheading:18037896-Cell Nucleus,
pubmed-meshheading:18037896-Humans,
pubmed-meshheading:18037896-Mice,
pubmed-meshheading:18037896-Mice, Knockout,
pubmed-meshheading:18037896-Myocardium,
pubmed-meshheading:18037896-Myocytes, Cardiac,
pubmed-meshheading:18037896-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:18037896-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:18037896-Proto-Oncogene Proteins c-pim-1,
pubmed-meshheading:18037896-Rats,
pubmed-meshheading:18037896-bcl-X Protein
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pubmed:year |
2007
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pubmed:articleTitle |
Pim-1 regulates cardiomyocyte survival downstream of Akt.
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pubmed:affiliation |
San Diego State University Heart Institute, San Diego State University, 5500 Campanile Drive, San Diego, California 92182, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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