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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-2-7
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pubmed:abstractText |
Peritoneal fibrosis (PF), a serious problem in long-term continuous ambulatory peritoneal dialysis (CAPD) patients, is characterized by extracellular matrix (ECM) accumulation which results from an imbalance between the synthesis and the degradation of ECM components. Previous studies have demonstrated that ECM synthesis is increased in human peritoneal mesothelial cells (HPMCs) under high glucose conditions, but the effects of high glucose on degradative pathways have not been fully explored. This study was undertaken to elucidate the effects of high glucose on these proteolytic processes in cultured HMPCs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1460-2385
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pubmed:author |
pubmed-author:ChoiHoon YoungHY,
pubmed-author:HanDae SukDS,
pubmed-author:HanSeung HyeokSH,
pubmed-author:JungDong-SubDS,
pubmed-author:KangShin-WookSW,
pubmed-author:KimHyung JongHJ,
pubmed-author:KimJin-JuJJ,
pubmed-author:KimKyung SikKS,
pubmed-author:KwakSeung-JaeSJ,
pubmed-author:LiJin-JiJJ,
pubmed-author:RyuDong-RyeolDR,
pubmed-author:YooTae-HyunTH,
pubmed-author:YoonSoo YoungSY
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pubmed:issnType |
Electronic
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
534-41
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pubmed:meshHeading |
pubmed-meshheading:18037618-Cells, Cultured,
pubmed-meshheading:18037618-Collagenases,
pubmed-meshheading:18037618-Epithelial Cells,
pubmed-meshheading:18037618-Fibrillar Collagens,
pubmed-meshheading:18037618-Fibrosis,
pubmed-meshheading:18037618-Glucose,
pubmed-meshheading:18037618-Humans,
pubmed-meshheading:18037618-Peritoneum,
pubmed-meshheading:18037618-RNA, Messenger,
pubmed-meshheading:18037618-Tissue Inhibitor of Metalloproteinases
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pubmed:year |
2008
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pubmed:articleTitle |
High glucose decreases collagenase expression and increases TIMP expression in cultured human peritoneal mesothelial cells.
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pubmed:affiliation |
Yonsei University College of Medicine, Department of Internal Medicine, 134 Shinchon-Dong Seodaemoon-Gu, Seoul, Korea, 120-752.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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