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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-1-14
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pubmed:abstractText |
A retrospective clinical and immunological survey was conducted in 60 patients with Chronic Granulomatous Disease. A prospective controlled non-randomized study of the efficacy of long-term IFNgamma treatment was carried out. The mean age at the time of diagnosis was 4.4 years; mean duration of follow-up was 10.4 years. Lung and skin infections were the most frequent manifestations both prior to diagnosis and during follow-up. Aspergillus species was the first cause of infection and of death in our cohort. The mortality rate was 13%. Long term prophylaxis with IFNgamma did not significantly change the rate of total infection per patient-year compared to controls (p=0.07). Our data provide clear evidence that protocols of continuing intensive surveillance and monitoring of compliance with anti-infective regimens may significantly improve the quality of life and long-term survival in patients with CGD. No evidence justifying long-term prophylaxis with IFNgamma was obtained.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1521-6616
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pubmed:author |
pubmed-author:AzzariChiaraC,
pubmed-author:BroccolettiTeresaT,
pubmed-author:CarpinoLuigiL,
pubmed-author:CossuFaustoF,
pubmed-author:De MattiaDomenicoD,
pubmed-author:DellepianeRosa MRM,
pubmed-author:Di BartolomeoPaoloP,
pubmed-author:FinocchiAndreaA,
pubmed-author:GattornoMarcoM,
pubmed-author:IPINET,
pubmed-author:LocatelliFrancoF,
pubmed-author:MaccarioRitaR,
pubmed-author:MartinoSilvanaS,
pubmed-author:MartireBaldassarreB,
pubmed-author:NotarangeloLuigi DLD,
pubmed-author:PieraniPaoloP,
pubmed-author:PietrograndeMaria CMC,
pubmed-author:PignataClaudioC,
pubmed-author:PlebaniAlessandroA,
pubmed-author:PuttiMaria CMC,
pubmed-author:RabusinMarcoM,
pubmed-author:RondelliRobertoR,
pubmed-author:RossiPaoloP,
pubmed-author:SoresinaAnnarosaA,
pubmed-author:StabileAchilleA,
pubmed-author:TrizzinoAntoninoA,
pubmed-author:UgazioAlberto GAG
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pubmed:issnType |
Print
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
155-64
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18037347-Anti-Infective Agents,
pubmed-meshheading:18037347-Antifungal Agents,
pubmed-meshheading:18037347-Antiviral Agents,
pubmed-meshheading:18037347-Bacterial Infections,
pubmed-meshheading:18037347-Child,
pubmed-meshheading:18037347-Child, Preschool,
pubmed-meshheading:18037347-Cohort Studies,
pubmed-meshheading:18037347-Female,
pubmed-meshheading:18037347-Follow-Up Studies,
pubmed-meshheading:18037347-Granulomatous Disease, Chronic,
pubmed-meshheading:18037347-Humans,
pubmed-meshheading:18037347-Infant,
pubmed-meshheading:18037347-Interferon-gamma,
pubmed-meshheading:18037347-Italy,
pubmed-meshheading:18037347-Itraconazole,
pubmed-meshheading:18037347-Kaplan-Meier Estimate,
pubmed-meshheading:18037347-Male,
pubmed-meshheading:18037347-Retrospective Studies,
pubmed-meshheading:18037347-Treatment Outcome,
pubmed-meshheading:18037347-Trimethoprim-Sulfamethoxazole Combination
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pubmed:year |
2008
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pubmed:articleTitle |
Clinical features, long-term follow-up and outcome of a large cohort of patients with Chronic Granulomatous Disease: an Italian multicenter study.
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pubmed:affiliation |
Dipartimento di Biomedicina dell'Età Evolutiva, Università di Bari, Italy. baldo.martire@bioetaev.uniba.it
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pubmed:publicationType |
Journal Article,
Multicenter Study
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