Linked Life Data

18036196

Source:http://linkedlifedata.com/resource/pubmed/id/18036196

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pubmed-article:18036196pubmed:abstractTextThe c-Jun N-terminal kinase 1 (JNK1, mitogen-activated kinase 8; MAPK8) phosphorylates insulin receptor substrate-1 (IRS-1) at serine 307, which induces insulin resistance. MAPK8 activity is increased in obese insulin-resistant mice, whereas mapk8 (-/-) mice show decreased adiposity and improved insulin sensitivity. The aim of this study was to determine the relationship between single nucleotide polymorphisms (SNPs) of MAPK8 and type 2 diabetes (T2DM).lld:pubmed
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pubmed-article:18036196pubmed:articleTitleThe G/G genotype of a single nucleotide polymorphism at -1066 of c-Jun N-terminal kinase 1 gene (MAPK8) does not affect type 2 diabetes susceptibility despite the specific binding of AP2alpha.lld:pubmed
pubmed-article:18036196pubmed:affiliationDepartment of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime Japan. harosawa@m.ehime-u.ac.jplld:pubmed
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pubmed-article:18036196pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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