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rdf:type |
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lifeskim:mentions |
umls-concept:C0001721,
umls-concept:C0011860,
umls-concept:C0012655,
umls-concept:C0017337,
umls-concept:C0017431,
umls-concept:C0205369,
umls-concept:C0380051,
umls-concept:C0752046,
umls-concept:C1167622,
umls-concept:C1319635,
umls-concept:C1367731
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pubmed:issue |
1
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pubmed:dateCreated |
2008-7-7
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pubmed:abstractText |
The c-Jun N-terminal kinase 1 (JNK1, mitogen-activated kinase 8; MAPK8) phosphorylates insulin receptor substrate-1 (IRS-1) at serine 307, which induces insulin resistance. MAPK8 activity is increased in obese insulin-resistant mice, whereas mapk8 (-/-) mice show decreased adiposity and improved insulin sensitivity. The aim of this study was to determine the relationship between single nucleotide polymorphisms (SNPs) of MAPK8 and type 2 diabetes (T2DM).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1365-2265
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pubmed:author |
pubmed-author:FujiiYasuhisaY,
pubmed-author:KawamotoRyuichiR,
pubmed-author:MakinoHideichiH,
pubmed-author:MikiTetsuroT,
pubmed-author:NishidaWataruW,
pubmed-author:OchiMasaakiM,
pubmed-author:OhashiJunJ,
pubmed-author:OnumaHiroshiH,
pubmed-author:OsawaHaruhikoH,
pubmed-author:ShimizuIkkiI,
pubmed-author:TabaraYasuharuY,
pubmed-author:YamadaKazuyaK
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pubmed:issnType |
Electronic
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
36-44
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18036196-3T3-L1 Cells,
pubmed-meshheading:18036196-Aged,
pubmed-meshheading:18036196-Animals,
pubmed-meshheading:18036196-Binding Sites,
pubmed-meshheading:18036196-Case-Control Studies,
pubmed-meshheading:18036196-Cells, Cultured,
pubmed-meshheading:18036196-Diabetes Mellitus, Type 2,
pubmed-meshheading:18036196-Female,
pubmed-meshheading:18036196-Genetic Predisposition to Disease,
pubmed-meshheading:18036196-Genotype,
pubmed-meshheading:18036196-Humans,
pubmed-meshheading:18036196-Linkage Disequilibrium,
pubmed-meshheading:18036196-Male,
pubmed-meshheading:18036196-Mice,
pubmed-meshheading:18036196-Middle Aged,
pubmed-meshheading:18036196-Mitogen-Activated Protein Kinase 8,
pubmed-meshheading:18036196-Polymorphism, Single Nucleotide,
pubmed-meshheading:18036196-Promoter Regions, Genetic,
pubmed-meshheading:18036196-Protein Binding,
pubmed-meshheading:18036196-Substrate Specificity,
pubmed-meshheading:18036196-Transcription Factor AP-2
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pubmed:year |
2008
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pubmed:articleTitle |
The G/G genotype of a single nucleotide polymorphism at -1066 of c-Jun N-terminal kinase 1 gene (MAPK8) does not affect type 2 diabetes susceptibility despite the specific binding of AP2alpha.
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pubmed:affiliation |
Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime Japan. harosawa@m.ehime-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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