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rdf:type |
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lifeskim:mentions |
umls-concept:C0007226,
umls-concept:C0008976,
umls-concept:C0011860,
umls-concept:C0013072,
umls-concept:C0017431,
umls-concept:C0018595,
umls-concept:C0023981,
umls-concept:C0042874,
umls-concept:C0237401,
umls-concept:C0392756,
umls-concept:C0441471,
umls-concept:C1515021,
umls-concept:C1515075
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pubmed:issue |
2
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pubmed:dateCreated |
2008-1-24
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pubmed:databankReference |
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pubmed:abstractText |
Clinical trials of vitamin E have failed to demonstrate a decrease in cardiovascular events. However, these studies did not address possible benefit to subgroups with increased oxidative stress. Haptoglobin (Hp), a major antioxidant protein, is a determinant of cardiovascular events in patients with Type 2 diabetes mellitus (DM). The Hp gene is polymorphic with 2 common alleles, 1 and 2. The Hp 2 allelic protein product provides inferior antioxidant protection compared with the Hp 1 allelic product. We sought to test the hypothesis that vitamin E could reduce cardiovascular events in DM individuals with the Hp 2-2 genotype, a subgroup that comprises 2% to 3% of the general population.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1524-4636
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pubmed:author |
pubmed-author:AlshiekJuniaJ,
pubmed-author:AnbinderYefimY,
pubmed-author:AronsonDoronD,
pubmed-author:BennettLawrenceL,
pubmed-author:BlumShanyS,
pubmed-author:KeidarShlomoS,
pubmed-author:KhemlinAlexanderA,
pubmed-author:KostenkoMariaM,
pubmed-author:LandauMicheleM,
pubmed-author:LevyAndrew PAP,
pubmed-author:LevyYishaiY,
pubmed-author:Miller-LotanRachelR,
pubmed-author:MilmanUziU,
pubmed-author:RadanArmanA,
pubmed-author:ShapiraChenC
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
341-7
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pubmed:meshHeading |
pubmed-meshheading:18032779-Aged,
pubmed-meshheading:18032779-Antioxidants,
pubmed-meshheading:18032779-Diabetes Mellitus, Type 2,
pubmed-meshheading:18032779-Double-Blind Method,
pubmed-meshheading:18032779-Female,
pubmed-meshheading:18032779-Genetic Predisposition to Disease,
pubmed-meshheading:18032779-Genotype,
pubmed-meshheading:18032779-Haptoglobins,
pubmed-meshheading:18032779-Homozygote,
pubmed-meshheading:18032779-Humans,
pubmed-meshheading:18032779-Male,
pubmed-meshheading:18032779-Middle Aged,
pubmed-meshheading:18032779-Myocardial Infarction,
pubmed-meshheading:18032779-Oxidative Stress,
pubmed-meshheading:18032779-Pharmacogenetics,
pubmed-meshheading:18032779-Prospective Studies,
pubmed-meshheading:18032779-Stroke,
pubmed-meshheading:18032779-Tocopherols
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pubmed:year |
2008
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pubmed:articleTitle |
Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype: a prospective double-blinded clinical trial.
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pubmed:affiliation |
Clalit Health Services, Haifa, Israel.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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