Linked Life Data

18032029

Source:http://linkedlifedata.com/resource/pubmed/id/18032029

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-12-10
pubmed:abstractText
The past fifteen years have witnessed great progress in our undestanding of how natural killer (NK) cells function, their role in innate defenses and their possible exploitation in therapy. This contribution traces the major advances in these formerly mysterious cells, from the first discovery of HLA-class I-specific inhibitory receptors to a more recent major breakgthrough that highlighted important perspectives and major expectations regarding the cure of life-threatening leukemias. The key role of "alloreactive" NK cells in eradicating acute myeloid leukemias and in preventing both graft rejection and graft-versus-host disease, led to a true revolution in bone marrow transplantation. Thus, it is now possible to search for appropriate HLA class I mismatches to set NK cells in action to cure high risk leukemias.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0960-7404
pubmed:author
pubmed:issnType
Print
pubmed:volume
16 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S3-5
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
NK cell-mediated immune response against cancer.
pubmed:affiliation
Department of Experimental Medicine, Giannina Gaslini Institute, University of Genova, Center of Excellence for Biomedical Research, Genova, Italy. lorenzomoretta@ospedale-gaslini.ge.it
pubmed:publicationType
Journal Article, Review