Source:http://linkedlifedata.com/resource/pubmed/id/18031946
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2007-12-6
|
| pubmed:abstractText |
The insulin-like growth factor1 (IGF1) pathway plays a significant role in both the normal and malignant cell growth. IGF1 binds to the IGF1 receptor and starts a signaling cascade that regulates cell proliferation, differentiation, and apoptosis. The bioavailability of IGF1 is regulated by the binding protein IGFBP3. A CA repeat polymorphism, in the IGF1 gene, which is located 969 bp upstream from the transcription start site and the rs2854744 and rs2854746 single nucleotide polymorphisms (SNPs) in the IGFBP3 gene have been associated with the serum levels of the respective proteins and colorectal cancer (CRC), but the results are inconsistent. We wanted to study if these polymorphisms or any haplotypes of the IGF1 and the IGFBP3 genes are associated with CRC.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1525-1500
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
408-16
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| pubmed:meshHeading |
pubmed-meshheading:18031946-Adult,
pubmed-meshheading:18031946-Aged,
pubmed-meshheading:18031946-Aged, 80 and over,
pubmed-meshheading:18031946-Case-Control Studies,
pubmed-meshheading:18031946-Colorectal Neoplasms,
pubmed-meshheading:18031946-Female,
pubmed-meshheading:18031946-Genetic Predisposition to Disease,
pubmed-meshheading:18031946-Genotype,
pubmed-meshheading:18031946-Haplotypes,
pubmed-meshheading:18031946-Humans,
pubmed-meshheading:18031946-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:18031946-Insulin-Like Growth Factor I,
pubmed-meshheading:18031946-Linkage Disequilibrium,
pubmed-meshheading:18031946-Male,
pubmed-meshheading:18031946-Middle Aged,
pubmed-meshheading:18031946-Polymerase Chain Reaction,
pubmed-meshheading:18031946-Polymorphism, Single Nucleotide,
pubmed-meshheading:18031946-Risk Factors
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Polymorphisms in the insulin like growth factor 1 and IGF binding protein 3 genes and risk of colorectal cancer.
|
| pubmed:affiliation |
Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|