Linked Life Data

18031345

Source:http://linkedlifedata.com/resource/pubmed/id/18031345

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-11-22
pubmed:abstractText
The observation that accumulation of the amino acid glycine is associated with strong growth inhibition or even death in cyanobacteria, plants and humans led to the hypothesis that glycine might act toxically if a certain threshold is exceeded. In this report, it is shown that Synechocystis PCC 6803 wild-type cells could sustain higher glycine addition than mutants impaired in enzymes using glycine such as the T-protein of the glycine decarboxylase complex or PurT involved in purine biosynthesis. A mutant defective in the glycine uptake system was barely influenced by external glycine. This shows that the intracellular level of accumulated glycine is critical. The toxic effect could be alleviated by addition of MgCl(2), suggesting that glycine might be toxic by reducing intracellular Mg(2+) ions, which are essential for many vital processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0378-1097
pubmed:author
pubmed:issnType
Print
pubmed:volume
277
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
232-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Glycine accumulation is toxic for the cyanobacterium Synechocystis sp. strain PCC 6803, but can be compensated by supplementation with magnesium ions.
pubmed:publicationType
Letter, Research Support, Non-U.S. Gov't