Linked Life Data

18031242

Source:http://linkedlifedata.com/resource/pubmed/id/18031242

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 6
pubmed:dateCreated
2007-11-22
pubmed:abstractText
Infectious disease is a formidable selective force in Nature as is evident from the complexity of immune systems across multicellular species. TLRs (Toll-like receptors) constitute central pattern-recognition molecules of the innate immune system that sense bacterial, viral, fungal, protozoan and helminth organisms and activate responses that provide immediate as well as long-term protection for the host. The present article reviews the function and evolution of vertebrate TLRs with an emphasis on the subfamily of receptors comprising human TLR1, 2, 6 and 10. The idea that TLRs undergo strong purifying selection provides the framework for the discussion of single nucleotide polymorphisms, many of which are associated with the incidence of infectious disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0300-5127
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1445-8
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Genetic polymorphisms within the human Toll-like receptor 2 subfamily.
pubmed:affiliation
Department of Microbiology and College of Medicine, University of Illinois at Urbana/Champaign, Urbana, IL 61821, USA. tapping@life.uiuc.edu
pubmed:publicationType
Journal Article, Review