Linked Life Data

18029716

Source:http://linkedlifedata.com/resource/pubmed/id/18029716

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
51
pubmed:dateCreated
2007-11-21
pubmed:abstractText
Electrochemical biosensors for the detection of specific DNA sequences have been described. The redox-modified DNA sequences were hybridized with the 3'-thiol-modified DNA sequences as capture DNA strand. The resulting duplexes were assembled on a gold electrode surface to make DNA chip. Upon addition of fully complementary DNA or mismatch-containing DNA, the time-dependent changes in redox signal were monitored. Mismatched DNA gave less than 20% change when compared with fully matched DNA under the same conditions. The present assay format is thus applicable in discrimination of mutated DNA from fully matched DNA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1746-8272
pubmed:author
pubmed:issnType
Electronic
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
321-2
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Electrochemical biosensors based on DNA strand exchange.
pubmed:affiliation
Department of Materials Science and Chemistry, University of Hyogo, 2167 Shosha, Himeji 671-2201, Japan.
pubmed:publicationType
Journal Article