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rdf:type |
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lifeskim:mentions |
umls-concept:C0011854,
umls-concept:C0017262,
umls-concept:C0026473,
umls-concept:C0030705,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C0332120,
umls-concept:C0332307,
umls-concept:C0670896,
umls-concept:C1336636,
umls-concept:C1442792,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2008-2-8
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pubmed:abstractText |
Type 1 diabetes (T1DM) is associated with increased cardiovascular mortality. It is a pro-inflammatory state as evidenced by increased circulating biomarkers and monocyte activity. The toll-like receptors (TLRs) are pattern recognition receptors, expressed abundantly on monocytes. TLR2 and TLR4 are important in atherosclerosis. However, there is a paucity of data examining TLR2 and TLR4 expression in T1DM and examining its contribution to the proinflammatory state.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-10096789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-11368702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-11554921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-12351483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-12832330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-15034566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-15249654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-15565375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-15692810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-15699513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-15983263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-16026364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-16211093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-16505242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-16728431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-16781673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-16891671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-16924467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-16968805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-17053832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-17090751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-17100625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-17318230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-17426109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18029454-17686944
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1 Receptor-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/MYD88 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid Differentiation Factor 88,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/TLR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TLR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-972X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
578-83
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pubmed:dateRevised |
2010-9-15
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pubmed:meshHeading |
pubmed-meshheading:18029454-Adult,
pubmed-meshheading:18029454-Blotting, Western,
pubmed-meshheading:18029454-Diabetes Mellitus, Type 1,
pubmed-meshheading:18029454-Female,
pubmed-meshheading:18029454-Humans,
pubmed-meshheading:18029454-Interleukin-1 Receptor-Associated Kinases,
pubmed-meshheading:18029454-Interleukin-1beta,
pubmed-meshheading:18029454-Leukocytes, Mononuclear,
pubmed-meshheading:18029454-Male,
pubmed-meshheading:18029454-Myeloid Differentiation Factor 88,
pubmed-meshheading:18029454-NF-kappa B,
pubmed-meshheading:18029454-RNA, Messenger,
pubmed-meshheading:18029454-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18029454-Signal Transduction,
pubmed-meshheading:18029454-Statistics, Nonparametric,
pubmed-meshheading:18029454-Toll-Like Receptor 2,
pubmed-meshheading:18029454-Toll-Like Receptor 4,
pubmed-meshheading:18029454-Tumor Necrosis Factor-alpha
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pubmed:year |
2008
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pubmed:articleTitle |
Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state.
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pubmed:affiliation |
Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California 95817, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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