|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0027996,
umls-concept:C0041942,
umls-concept:C0205314,
umls-concept:C0205531,
umls-concept:C0226896,
umls-concept:C0243192,
umls-concept:C0442027,
umls-concept:C0597357,
umls-concept:C0679622,
umls-concept:C0935763,
umls-concept:C1510827,
umls-concept:C1527415,
umls-concept:C1539603,
umls-concept:C1880355
|
|
pubmed:issue |
24
|
|
pubmed:dateCreated |
2008-2-13
|
|
pubmed:abstractText |
A urea class of high affinity niacin receptor agonists was discovered. Compound 1a displayed good PK, better in vivo efficacy in reducing FFA in mouse than niacin, and no vasodilation in a mouse model. Compound 1q demonstrated equal affinity to GPR109A as niacin.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1464-3405
|
|
pubmed:author |
pubmed-author:CaiTian-QuanTQ,
pubmed-author:Carballo-JaneEsterE,
pubmed-author:ChengKangK,
pubmed-author:CollettiSteven LSL,
pubmed-author:DengQiaolinQ,
pubmed-author:HammondMilton LML,
pubmed-author:KharbandaDivyaD,
pubmed-author:RenNingN,
pubmed-author:ShenHong CHC,
pubmed-author:SzymonifkaMichael JMJ,
pubmed-author:TaggartAndrew KAK,
pubmed-author:TataJames RJR,
pubmed-author:TongXinchunX,
pubmed-author:WangJunyingJ,
pubmed-author:WatersM GerardMG,
pubmed-author:WuKenneth KKK,
pubmed-author:WuTsuei-JuTJ
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6723-8
|
|
pubmed:dateRevised |
2011-11-3
|
|
pubmed:meshHeading |
pubmed-meshheading:18029181-Animals,
pubmed-meshheading:18029181-Combinatorial Chemistry Techniques,
pubmed-meshheading:18029181-Humans,
pubmed-meshheading:18029181-Male,
pubmed-meshheading:18029181-Mice,
pubmed-meshheading:18029181-Models, Animal,
pubmed-meshheading:18029181-Molecular Structure,
pubmed-meshheading:18029181-Niacin,
pubmed-meshheading:18029181-Receptors, G-Protein-Coupled,
pubmed-meshheading:18029181-Receptors, Nicotinic,
pubmed-meshheading:18029181-Structure-Activity Relationship,
pubmed-meshheading:18029181-Urea,
pubmed-meshheading:18029181-Vasodilation
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A.
|
|
pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA. hong_shen@merck.com
|
|
pubmed:publicationType |
Journal Article
|
