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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0002482,
umls-concept:C0166417,
umls-concept:C0205314,
umls-concept:C0208973,
umls-concept:C0220781,
umls-concept:C0243192,
umls-concept:C0439097,
umls-concept:C0679622,
umls-concept:C1517892,
umls-concept:C1547348,
umls-concept:C1554184,
umls-concept:C1704666,
umls-concept:C1705241,
umls-concept:C1707689,
umls-concept:C1883254
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pubmed:issue |
24
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|
pubmed:dateCreated |
2008-2-13
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|
pubmed:abstractText |
A series of potent amide linked PPARgamma/delta dual agonists (1a) has been discovered through rational design. In the ZDF rat model of type 2 diabetes, compound (R)-3-[4-(3-{1-[(5-chloro-1,3-dimethyl-1H-indole-2-carbonyl)-amino]-ethyl}-5-fluoro-phenoxy)-2-ethyl-phenyl]-propionic acid (42) from this series has demonstrated glucose lowering efficacy comparable to the marketed PPARgamma agonist rosiglitazone with less weight gain.
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|
pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Dec
|
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pubmed:issn |
1464-3405
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|
pubmed:author |
pubmed-author:BroderickCarol LCL,
pubmed-author:CanadaEmily JEJ,
pubmed-author:ClutingerCathleen KCK,
pubmed-author:EtgenGarret JGJ,
pubmed-author:IrwinLynnie ALA,
pubmed-author:LaurilaMichael EME,
pubmed-author:MantloNathanN,
pubmed-author:Montrose-RafizadehChahrzadC,
pubmed-author:OldhamBrian ABA,
pubmed-author:ShiQingQ,
pubmed-author:WangMinminM,
pubmed-author:WarshawskyAlan MAM,
pubmed-author:WinneroskiLeonard LLL,
pubmed-author:XieChaoyuC,
pubmed-author:XuYanpingY,
pubmed-author:YorkJeremy SJS,
pubmed-author:YumibeNathan PNP,
pubmed-author:ZinkRichard WRW
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|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
6744-9
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|
pubmed:meshHeading |
pubmed-meshheading:18029178-Amides,
pubmed-meshheading:18029178-Animals,
pubmed-meshheading:18029178-Combinatorial Chemistry Techniques,
pubmed-meshheading:18029178-Diabetes Mellitus, Type 2,
pubmed-meshheading:18029178-Disease Models, Animal,
pubmed-meshheading:18029178-Drug Design,
pubmed-meshheading:18029178-Indoles,
pubmed-meshheading:18029178-Molecular Structure,
pubmed-meshheading:18029178-PPAR delta,
pubmed-meshheading:18029178-PPAR gamma,
pubmed-meshheading:18029178-Rats
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists.
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|
pubmed:affiliation |
Eli Lilly and Company, Lilly Research Labs, Lilly Corporate Center, Indianapolis, IN 46285, USA. shi_qing@lilly.com
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pubmed:publicationType |
Journal Article
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